国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (12): 932-935.

• 综述 • 上一篇    下一篇

恶性气管食管瘘的研究进展

徐广, 于会明, 韩大力, 于金明   

  1. 262300 山东省五莲县人民医院肿瘤科(徐广);山东省立医院肿瘤科(于会明);山东省肿瘤医院放疗科 山东省放射肿瘤学重点实验室(韩大力、于金明)
  • 出版日期:2012-12-08 发布日期:2012-11-15
  • 通讯作者: 韩大力,E-mail:dalihan2008@163.com E-mail:dalihan2008@163.com
  • 基金资助:

    国家自然科学基金资助项目(81101699、81172596)山东省自然科学基金资助项目(ZR2011HLO059)

Study progress of malignant tracheoesophageal fistula

XU  Guang, YU  Hui-Ming, HAN  Da-Li, YU  Jin-Ming   

  1. Department of Oncology, Wulian County Hospital, Rizhao 262300, China
  • Online:2012-12-08 Published:2012-11-15
  • Contact: Corresponding author:HAN Da-li, E-mail:dalihan2008@163.com E-mail:dalihan2008@163.com

摘要: 恶性气管食管瘘(MTEF)是恶性肿瘤累及气管或支气管壁及食管而引起的气管、支气管等呼吸道与食管的病理性交通。MTEF的诊断需要食管造影来确定,瘘口的位置和大小往往需要进一步行支气管镜和食管镜检查来确定。一旦发生MTEF后往往预后不良,治疗措施多以姑息症状和改善生活质量为目的。治疗需要根据患者进行个体化选择,包括食管支架置入术、食管旷置和旁路替代、瘘管切除和修补、放射治疗等手段,可以延长部分患者的生存期,改善生活质量。MTEF不是化放疗的绝对禁忌证,化放疗尽管可能会合并急性毒性反应,但只要如果能够成功控制瘘口,可使一般情况好、无远处转移的患者获得较长的生存期。

关键词: 气管食管瘘, 支架, 外科手术, 放射疗法, 药物疗法

Abstract: Malignant tracheoesophageal fistula (MTEF) is pathological communication between the respiratory tracts such as the trachea or bronchia and the esophagus because of malignant tumor dissemination through them. Radiography is an important adjunctive technology in the diagnosis of MTEF, and the location and size of fistula often need the further diagnosis of bronchoscopy and esophagoscopy. The patients are often with an unfavourable prognosis once developed MTEF, and are treated usually with the aim of symptom palliation and life quality improvement. The individual treatment includes esophageal stenting, esophageal exclusion and esophagus bypass, fistula exclusion and repair, radiotherapy and others effective therapy according to the patients condition. These therapies will prolong the life span and improve the life quality of patients. MTEF is not absolute contraindication for chemoradiotherapy. Despite its acute toxicity, this concurrent chemoradiotherapy protocol appears feasible and effective at closing esophageal malignant fistula, especially in patients in a good general condition and without metastasis.

Key words: Tracheoesophageal fistula, Seents, Surgical procedures, operative, Radiotherapy, Drug therapy