国际肿瘤学杂志

国际肿瘤学杂志 ›› 2011, Vol. 38 ›› Issue (8): 596-598.

• 综述 • 上一篇    下一篇

树突状细胞疫苗治疗脑胶质瘤进展

徐昊, 王占祥   

  1. 厦门大学附属第一医院神经外科
  • 收稿日期:2011-03-15 修回日期:2011-07-12 出版日期:2011-08-08 发布日期:2011-08-29
  • 通讯作者: 徐昊 E-mail:tony_xuhao@189.cn

Research advance of Dendritic cell vaccines to combat glioma

XU  Hao, WANG  Zhan-Xiang   

  • Received:2011-03-15 Revised:2011-07-12 Online:2011-08-08 Published:2011-08-29

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摘要： 树突状细胞介导的肿瘤疫苗应用于脑胶质瘤治疗，通过选择更合适的靶点，增强了DC疫苗的特异性。由基因工程转入抗细胞凋亡蛋白，获得了寿命更长、效能更高的DC疫苗。随着临床经验的积累，DC疫苗的疗效得到了显著提高。

关键词: 树突状细胞, 胶质瘤, 肿瘤疫苗, 免疫疗法

Abstract: Dendritic cell (DC)-based vaccine therapies represent a novel experimental approach to treat malignant gliomas.Target selection heightens the specificity of vaccine,while engineering of highly immunogenic long-lived DC vaccines by antiapoptotic protein gene transfer enhances the cancer vaccine potency.With the accumulation of clinical experience，it can improve clinical curative effect in the treatment of paitients.

Key words: Dendritic cell, Glioma, Cancer vaccines, Immunotherapy