国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (11): 824-827.doi: 10.3760/cma.j.issn.1673422X.2017.11.005

• 论著 • 上一篇    下一篇

外周血中性粒细胞-淋巴细胞比值在三阴性乳腺癌患者预后分析中的价值

潘宇凯   

  1. 214400 江苏省江阴市人民医院肿瘤内科
  • 收稿日期:2017-03-01 出版日期:2017-11-08 发布日期:2017-11-24
  • 通讯作者: 潘宇凯 E-mail:845386454@qq.com

Valuation of neutrophil to lymphocyte ratio in peripheral blood as a prognostic factor for patients with triple negative breast cancer

Pan Yukai   

  1. Department of Oncology, People′s Hospital of Jiangyin, Jiangsu Province, Jiangyin 214400, China
  • Received:2017-03-01 Online:2017-11-08 Published:2017-11-24
  • Contact: 潘宇凯 E-mail:845386454@qq.com

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摘要： 目的研究三阴性乳腺癌（TNBC）患者临床特征及预后相关影响因素，分析术前外周血中性粒细胞淋巴细胞比值（NLR）与TNBC患者预后的关系，探讨NLR作为TNBC患者预后指标的作用价值。方法对江苏省江阴市人民医院肿瘤科2008年1月至2013年1月收治的87例TNBC患者的临床资料进行统计分析，根据患者术前外周血NLR分为低NLR组（NLR≤4.39）58例和高NLR组（NLR＞4.39）29例，分析NLR与患者临床病理特征的关系，采用KaplanMeier法进行生存分析并进行单因素分析、Cox比例风险回归模型多因素分析，探讨术前外周血NLR等因素对TNBC患者生存期的影响。结果术前外周血NLR与临床分期（χ2=8.628，P=0.005）及淋巴结转移（χ2=4.911，P=0.027）有关，与年龄（χ2=0.575，P=0.448）、病理类型（χ2=0.687，P=0.709）、肿瘤大小（χ2=3.523，P=0.172）、是否吸烟（χ2=0.536，P=0.474）、是否饮酒（χ2=0.043，P=0.837）、家族史（χ2=0.315，P=0.585）均无关。单因素分析结果显示，淋巴结转移（HR=2.02，P=0.021）、临床分期（HR=2.69，P=0.007）、NLR（HR=2.26，P=0.014）与患者的总生存期相关。Cox比例风险回归模型多因素分析结果显示，临床分期（HR=4.10，P=0.033）和NLR（HR=3.44，P=0.016）是TNBC患者不良预后的独立影响因素。结论NLR与TNBC临床肿瘤分期和淋巴结状态密切相关，高NLR是一个较新的TNBC患者预后独立危险因素，对患者预后判断有重要的提示作用。

关键词: 乳腺肿瘤, 淋巴细胞, 预后, 回顾性研究

Abstract: ObjectiveTo analyze the clinical features of patients with triplenegative breast cancer (TNBC) and prognostic factors, and to analyze the correlation between neutrophiltolymphocyte ratio (NLR) in peripheral blood before operation and the prognosis of TNBC patients and investigate the value of NLR as a prognostic index for patients with TNBC. MethodsThe clinical data of 87 patients with TNBC treated in People′s Hospital of Jiangyin of Jiangsu Province from January 2008 to January 2013 were analyzed retrospectively. The patients were divided into low NLR group (NLR≤4.39, n=58) and high NLR group (NLR＞4.39, n=29) according to the NLR in peripheral blood before operation. The correlations between NLR and clinicpathological features were analyzed. KaplanMeier method was used to estimate the survival. The univariate analysis was done and Cox proportional hazards regression model was used for multivariate analysis to explore the effect of the NLR in peripheral blood before operation on survival of TNBC patients. ResultsThe high NLR value was related with the clinical stage (χ2=8.628, P=0.005) and lymph node metastasis (χ2=4.911, P=0.027). However, NLR was not correlated with age (χ2=0.575, P=0.448), pathological types (χ2=0.687，P=0.709), tumor size (χ2=3.523, P=0.172), smoking (χ2=0.536， P=0.474), drinking (χ2=0.043, P=0.837) or inheritance (χ2=0.315, P=0.585). Univariate analysis showed that lymph node metastasis (HR=2.02, P=0.021), clinical stage (HR=2.69, P=0.007) and NLR value (HR=2.26, P=0.014) were related to the overall survival of patients with TNBC. Cox multivariate analysis showed that clinical stage (HR=4.10, P=0.033) and NLR value (HR=3.44, P=0.016) were independent predictors of prognosis in patients with TNBC. ConclusionIn TNBC, the NLR level is related to clinical tumor stage and lymph node metastasis significantly. Furthermore, the higher NLR value is a novel independent prognostic risk factor, which has important implications on prognosis of patients with TNBC.

Key words: Breast neoplasms, Lymphocytes, Prognosis, Retrospective studies