18F-FDG PET-CT在鼻咽癌中的应用

doi:10.3760/cma.j.issn.1673422X.2016.08.013

摘要/Abstract

摘要： 18F-氟脱氧葡萄糖正电子发射计算机断层显像（18F-FDG PET-CT）是功能影像与解剖图像的组合，在鼻咽癌的TNM分期、靶区勾画、监测预后及发现肿瘤复发与残留等方面具有重要价值。将18F-FDG PET-CT和其他影像技术结合、开发不同的示踪剂、探测更多与鼻咽癌有关的特异性分子指标能提高18F-FDG PET-CT在鼻咽癌中的应用价值。

关键词: 鼻咽肿瘤, 放射治疗, 氟脱氧葡萄糖F18, 正电子发射断层显像术

Abstract: 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET-CT) is the integration of functional imaging and anatomic information, which is found to be particularly valuable in TNM staging, tumor volume delineating, posttreatment assessment, identification of recurrent and residual nasopharyngeal carcinoma (NPC). The combination of 18F-FDG PET-CT with other image technologies, different tracer agents, and specific molecular biomarkers can improve the application value of 18F-FDG PET-CT in NPC.

Key words: Nasopharyngeal neoplasms, Radiotherapy, Fluorodeoxyglucose F18, Positronemission tomography

罗丽,沈群,席许平,刘峰,肖锋. ¹⁸F-FDG PET-CT在鼻咽癌中的应用[J]. 国际肿瘤学杂志, 2016, 43(8): 615-618.

Luo Li, Shen Qun, Xi Xuping, Liu Feng, Xiao Feng.. Application of 18FFDG PETCT in nasopharyngeal carcinoma[J]. Journal of International Oncology, 2016, 43(8): 615-618.

参考文献

［1］ Leclerc M, Lartigau E, Lacornerie T, et al. Primary tumor delineation based on (18)FDG PET for locally advanced head and neck cancer treated by chemo-radiotherapy［J］. Radiother Oncol, 2015, 116(1): 87-93. DOI: 10.1016/j.radonc.2015.06.007. ［2］ Wei J, Pei S, Zhu X. Comparison of (18)F-FDG PET/CT, MRI and SPECT in the diagnosis of local residual/recurrent nasopharyngeal carcinoma: a meta-analysis［J］. Oral Oncol, 2016, 52(52): 11-17. DOI: 10.1016/j.oraloncology.2015.10.010. ［3］ Gordin A, Golz A, Daitzchman M, et al. Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography imaging in patients with carcinoma of the nasopharynx: diagnostic accuracy and impact on clinical management［J］. Int J Radiat Oncol Biol Phys, 2007, 68(2): 370-376. DOI: 10.1016/j.ijrobp.2006.12.028. ［4］ Anderson CM, Chang T, Graham MM, et al. Change of maximum standardized uptake value slope in dynamic triphasic ［18F］ fluorodeoxyglucose positron emission tomography/computed tomography distinguishes malignancy from postradiation inflammation in headandneck squamous cell carcinoma: a prospective trial［J］. Int J Radiat Oncol Biol Phys, 2015, 91(3): 472-479. DOI: 10.1016/j.ijrobp.2014.11.002. ［5］ Chan WK, Mak HK, Huang B, et al. Nasopharyngeal carcinoma: relationship between 18F-FDG PET-CT maximum standardized uptake value, metabolic tumour volume and total lesion glycolysis and TNM classification［J］. Nucl Med Commun, 2010, 31(3): 206-210. DOI: 10.1097/MNM.0b013e328333e3ef. ［6］ Ng SH, Chan SC, Yen TC, et al. Staging of untreated nasopharyngeal carcinoma with PET/CT: comparison with conventional imaging workup［J］. Eur J Nucl Med Mol Imaging, 2009, 36(1): 12-22. DOI: 10.1007/s00259-008-0918-7. ［7］ Vellayappan BA, Soon YY, Earnest A, et al. Accuracy of (18)F-flurodeoxyglucosepositron emission tomography/computed tomography in the staging of newly diagnosed nasopharyngeal carcinoma: a syste-matic review and metaanalysis［J］. Radiol Oncol, 2014, 48(4): 331-338. DOI: 10.2478/raon-2014-0011. ［8］林勤, 李夷民, 周原, 等. 18F-FDG PET/CT在鼻咽癌颈部淋巴结转移分期中的作用［J］. 中华核医学与分子影像杂志, 2012, 32(6): 418-421. DOI: 10.3760/cma.j.issn.20952848.2012.06.004. ［9］ Chang MC, Chen JH, Liang JA, et al. Accuracy of wholebody FDG-PET and FDG-PET/CT in M staging of nasopharyngeal carcinoma: a systematic review and metaanalysis［J］. Eur J Radiol, 2013, 82(2): 366-373. DOI: 10.1016/j.ejrad.2012.06.031. ［10］ Tang LQ, Chen QY, Fan W, et al. Prospective study of tailoring wholebody dualmodality ［18F］ fluorodeoxyglucose positron emission tomography/computed tomography with plasma EpsteinBarr virus DNA for detecting distant metastasis in endemic nasopharyngeal carcinoma at initial staging［J］. J Clin Oncol, 2013, 31(23): 2861-2869. DOI: 10.1200/JCO.2012.46.0816. ［11］ Law A, Peters LJ, Dutu G, et al. The utility of PET/CT in staging and assessment of treatment response of nasopharyngeal cancer［J］. J Med Imaging Radiat Oncol, 2011, 55(2): 199-205. DOI: 10.1111/j.17549485.2011.02252.x. ［12］林勤, 吴华, 朱鹭超, 等. FDG PET-CT与MRI在鼻咽癌原发灶靶区勾画中的对比研究［J］. 中华放射肿瘤学杂志, 2012, 21(6): 492-495. DOI: 10.3760/cma.j.issn.10044221.2012.06.003. ［13］ Delouya G, Igidbashian L, Houle A, et al. 18F-FDG-PET imaging in radiotherapy tumor volume delineation in treatment of head and neck cancer［J］. Radiother Oncol, 2011, 101(3): 362-368. DOI: 10.1016/j.radonc.2011.07.025. ［14］ Hung GU, Wu IS, Lee HS, et al. Primary tumor volume measured by FDG PET and CT in nasopharyngeal carcinoma［J］. Clin Nucl Med, 2011, 36(6): 447-451. DOI: 10.1097/RLU.0b013e31821738b8. ［15］邓翀, 林勤, 石丽婉, 等. 18F-FDG PET/CT勾画鼻咽癌原发肿瘤体积最适阈值的研究［J］. 中华放射医学与防护杂志, 2014, 34(7): 530-534. DOI: 10.3760/cma.j.issn.02545098.2014.07.013. ［16］ Meijer G, Steenhuijsen J, Bal M, et al. Dose painting by contours versus dose painting by numbers for stage Ⅱ/Ⅲ lung cancer: practical implications of using a broad or sharp brush［J］. Radiother Oncol, 2011, 100(3): 396-401. DOI: 10.1016/j.radonc.2011.08.048. ［17］ Duprez F, De Neve W, De Gersem W, et al. Adaptive dose painting by numbers for headand-neck cancer［J］. Int J Radiat Oncol Biol Phys, 2011, 80(4): 1045-1055. DOI: 10.1016/j.ijrobp.2010.03.028. ［18］ Chan SC, Chang JT, Lin CY, et al. Clinical utility of 18F-FDG PET parameters in patients with advanced nasopharyngeal carcinoma: predictive role for different survival endpoints and impact on prognostic stratification［J］. Nucl Med Commun, 2011, 32(11): 989-996. DOI: 10.1097/MNM.0b013e3283495662. ［19］ Liu WS, Wu MF, Tseng HC, et al. The role of pretreatment FDG-PET in nasopharyngeal carcinoma treated with intensitymodulated radiotherapy［J］. Int J Radiat Oncol Biol Phys, 2012, 82(2): 561-566. DOI: 10.1016/j.ijrobp.2010.11.055. ［20］ Hung TM, Wang HM, Kang CJ, et al. Pretreatment (18)FFDG PET standardized uptake value of primary tumor and neck lymph nodes as a predictor of distant metastasis for patients with nasopharyngeal carcinoma［J］. Oral Oncol, 2013, 49(2): 169-174. DOI: 10.1016/j.oraloncology.2012.08.011. ［21］ Chan SC, Kuo WH, Wang HM, et al. Prognostic implications of posttherapy (18)FFDG PET in patients with locoregionally advanced nasopharyngeal carcinoma treated with chemoradiotherapy［J］. Ann Nucl Med, 2013, 27(8): 710-719. DOI: 10.1007/s12149-013-0736-2. ［22］ Chan SC, Hsu CL, Yen TC, et al. The role of 18F-FDG PET/CT metabolic tumour volume in predicting survival in patients with metastatic nasopharyngeal carcinoma［J］. Oral Oncol, 2013, 49(1): 71-78. DOI: 10.1016/j.oraloncology.2012.07.016. ［23］ Moon SH, Choi JY, Lee HJ, et al. Prognostic value of volumebased positron emission tomography/computed tomography in patients with nasopharyngeal carcinoma treated with concurrent chemoradiotherapy［J］. Clin Exp Otorhinolaryngol, 2015, 8(2): 142-148. DOI: 10.3342/ceo.2015.8.2.142. ［24］ Shen G, Zhou L, Jia Z, et al. Metaanalysis of PET/CT for diagnosis of residual/recurrent nasopharyngeal carcinoma［J］. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2015, 29(1): 61-67. ［25］ Liu T, Xu W, Yan WL, et al. FDG-PET, CT, MRI for diagnosis of local residual or recurrent nasopharyngeal carcinoma, which one is the best? A systematic review［J］. Radiother Oncol, 2007, 85(3): 327-335. DOI: 10.1016/j.radonc.2007.11.002.

[1]	许凤琳, 吴刚. EBV在鼻咽癌肿瘤免疫微环境和免疫治疗中的研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 359-363.
[2]	崔腾璐, 孙鹏飞. 鼻咽低级别乳头状腺癌综合治疗1例并文献复习[J]. 国际肿瘤学杂志, 2023, 50(6): 382-384.
[3]	顾安琴, 龙金华, 金风. 鼻咽癌免疫治疗的临床研究进展[J]. 国际肿瘤学杂志, 2023, 50(5): 299-303.
[4]	李进芝, 赵彪, 文晓博, 张明, 袁美芳, 孙梦真, 蒲琴, 杨毅. Monaco系统计算网格尺寸对T₄期鼻咽癌的剂量学影响[J]. 国际肿瘤学杂志, 2023, 50(11): 641-649.
[5]	朱琪伟, 崔娟娟, 张紫寒, 杨燕光, 葛彬彬, 刘于, 储开岳. 左侧乳腺癌术后内乳区域淋巴结照射的心脏剂量学分析和生命质量评估[J]. 国际肿瘤学杂志, 2023, 50(1): 17-21.
[6]	郭延勇, 刘森, 高远. SBRT联合mFOLFOXIRI和西妥昔单抗在结直肠癌术后肝转移瘤中的临床疗效和不良反应[J]. 国际肿瘤学杂志, 2022, 49(6): 340-344.
[7]	孙晓琳, 张展昱, 许林宗, 刘英超, 李晓梅. 放疗联合免疫治疗在乳腺癌脑转移瘤中的潜在价值[J]. 国际肿瘤学杂志, 2022, 49(4): 243-246.
[8]	纪环, 周菊英, 马辰莺, 徐晓婷, 秦颂兵. 非小细胞肺癌脑转移的放疗进展[J]. 国际肿瘤学杂志, 2022, 49(3): 181-184.
[9]	李坪, 孙晓南. 体部立体定向放射治疗联合免疫检查点抑制剂在非小细胞肺癌中的应用[J]. 国际肿瘤学杂志, 2022, 49(2): 116-120.
[10]	中国医师协会放射肿瘤治疗医师分会, 中华医学会放射肿瘤治疗学分会, 中国抗癌协会肿瘤放射治疗专业委员会. 中国头颈部肿瘤放射治疗指南(2021年版)[J]. 国际肿瘤学杂志, 2022, 49(2): 65-72.
[11]	中华医学会数字医学分会, 重庆市医学会放射肿瘤治疗学专业委员会, 重庆市中西医结合学会肿瘤放疗专业委员会, 重庆市抗癌协会肿瘤放疗专业委员会. 鼻咽癌调强放疗靶区勾画重庆共识之原发灶与靶区设计[J]. 国际肿瘤学杂志, 2022, 49(12): 705-710.
[12]	陈方明, 蔡园园, 李晗, 王晓丽, 阚红星, 李洋, 郝福荣, 王明臣. 调强放疗鼻咽癌患者UICC第7版与第8版T分期预后差异[J]. 国际肿瘤学杂志, 2021, 48(9): 515-522.
[13]	中国医师协会放射肿瘤治疗医师分会. 脑转移瘤立体定向放射治疗临床指南[J]. 国际肿瘤学杂志, 2021, 48(8): 456-462.
[14]	彭亚, 柳岸, 刘火旺. PSD-007光动力疗法对荷人鼻咽癌裸鼠移植瘤的抑制作用及机制研究[J]. 国际肿瘤学杂志, 2021, 48(3): 136-142.
[15]	宋扬, 王斌, 肖何, 陈川, 王阁, 耿明英. 局部晚期鼻咽癌诱导化疗后肿瘤退缩率对患者生存的预测价值[J]. 国际肿瘤学杂志, 2021, 48(3): 156-163.

¹⁸F-FDG PET-CT在鼻咽癌中的应用

Application of 18FFDG PETCT in nasopharyngeal carcinoma

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价