国际肿瘤学杂志

国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (11): 845-848.doi: 10.3760/cma.j.issn.1673422X.2015.11.013

• 综述 • 上一篇    下一篇

基质金属蛋白酶-9在转移性乳腺癌中的研究现状

李莉, 孙蔚莉, 刘德林, 武渊, 王友群   

  1. 210009 南京，中国药科大学临床药学教研室（李莉、王友群）；江苏省肿瘤医院肿瘤内科（孙蔚莉、刘德林、武渊）
  • 出版日期:2015-11-08 发布日期:2015-09-30
  • 通讯作者: 孙蔚莉，Email:sunweili@medmail.com.cn；王友群，Email:wyqfbox@163.com E-mail:sunweili@medmail.com.cn;wyqfbox@163.com
  • 基金资助:

    江苏省肿瘤医院科研基金（ZM201204）

Research status of matrix metalloproteinase9 on metastatic breast cancer

Matrix metalloproteinase9 (MMP9) can promote the invasion and metastasis of breast cancer through various mechanisms. The expressions of MMP9 in the patients with breast cancer are correlated with the prognosis. The higher expression of MMP9 indicates poorer prognosis. It is suggested that the level change of MMP9 pre and post treatment can be used as a reference standard for judging the prognosis and clinical effect.   

  1. Department of Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China
  • Online:2015-11-08 Published:2015-09-30
  • Contact: Sun Weili; Wang Youqun E-mail:sunweili@medmail.com.cn;wyqfbox@163.com

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摘要： 基质金属蛋白酶9（MMP9）通过多种机制促进乳腺癌的侵袭、转移，其在乳腺癌患者体内的表达程度与预后存在一定的相关性。MMP9表达水平越高，预后可能越差。检测乳腺癌患者治疗前后体内MMP9表达水平的变化，可作为乳腺癌预后及治疗疗效的一种参考指标。

关键词: 基质金属蛋白酶9, 乳腺肿瘤, 预后, 参考标准

Abstract: Matrix metalloproteinase9 (MMP9) can promote the invasion and metastasis of breast cancer through various mechanisms. The expressions of MMP9 in the patients with breast cancer are correlated with the prognosis. The higher expression of MMP9 indicates poorer prognosis. It is suggested that the level change of MMP9 pre and post treatment can be used as a reference standard for judging the prognosis and clinical effect.

Key words: Matrix metalloproteinase 9, Breast neoplasms, Prognosis, Reference standards