国际肿瘤学杂志

国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (2): 95-98.doi: 10.3760/cma.j.issn.1673422X.2015.02.005

• 论著 • 上一篇    下一篇

IGF-1R和IGFBP-3在结肠癌中的表达及其与淋巴结转移的关系

李亭亭,康军朋,郭淑芹   

  1. 071000 保定市第一中心医院内分泌科
  • 出版日期:2015-02-08 发布日期:2015-02-02
  • 通讯作者: 郭淑芹 E-mail:gsq2011@163.com

Expressions of IGF-1R and IGFBP-3 in colon cancer metastasis and their correlations with lymphatic metastasis

Li Tingting, Kang Junpeng, Guo Shuqin   

  1. Department of Endocrinology, First Central Hospital of Baoding, Baoding 071000, China
  • Online:2015-02-08 Published:2015-02-02
  • Contact: Guo Shuqin E-mail:gsq2011@163.com

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摘要： 目的探讨胰岛素样生长因子1受体（IGF1R）和胰岛素样生长因子结合蛋白3（IGFBP3）在原发性结肠癌中的表达及与临床病理参数间的关系，以及二者在结肠癌淋巴结转移中的作用。方法应用免疫组织化学SP法检测78例结肠癌组织和78例正常结肠黏膜中IGF1R、IGFBP3的表达，并对二者的表达与结肠癌临床病理参数进行统计分析。结果IGF1R在结肠癌中的阳性率（66.7%，52/78)显著高于对照组（24.4%，19/78），χ2=28.150，P=0.000。IGFBP3在结肠癌中的阳性率（73.1%，57/78）显著低于对照组（89.7%，70/78)，χ2=7.158，P=0.007。IGF1R在结肠癌中的表达与浸润深度（χ2=5.804，P=0.016）、TNM分期（χ2=5.246，P=0.022）、淋巴结转移（χ2=12.955，P=0.000）呈明显相关性。IGFBP3在结肠癌中的表达与TNM分期（χ2=7.096，P=0.008）、淋巴结转移（χ2=5.893，P=0.015）、远处转移（P=0.003）呈明显相关性。二者均与其他因素无明显相关性（均P＞0.05）。IGF1R与IGFBP3的表达呈负相关（r=-0.245，P=0.03）。结论 IGF1R高表达和IGFBP3低表达与结肠癌TNM分期、淋巴结转移有关，IGF1R和IGFBP3可能成为治疗结肠癌新的作用靶点。

关键词: 结肠肿瘤, 受体, IGF1型, 胰岛素样生长因子结合蛋白质3, 免疫组织化学

Abstract: ObjectiveTo investigate the expressions of insulinlike growth factor receptor1 (IGF1R) and insulinlike growth factor binding protein3 (IGFBP3) and their correlations with clinicopathological parameters in the primary colon cancer, as well as their roles in lymph node metastasis of colon cancer. MethodsThe expressions of IGF1R and IGFBP3 in 78 cases of colon cancer tissues and 78 cases of normal colon mucosa tissues were detected by SP immunohistochemical technology and the correlations between the expressions and the clinical pathological parameters of colon cancer were analyzed. ResultsThe positive rate of IGF1R in colon cancer (66.7%, 52/78) was significantly higher than that in control group (24.4%, 19/78), χ2=28.150, P=0.000. The positive rate of IGFBP3 in colon cancer (73.1%, 57/78) was significantly lower than that in control group (89.7%, 70/78), χ2=7.158, P=0.007. IGF1R expression in colon cancer was significantly correlated with the invasion (χ2= 5.804, P=0.016), TNM stage (χ2=5.246, P=0.022) and lymph node metastasis (χ2=12.955, P=0.000). IGFBP3 expression in colon cancer was significantly correlated with the TNM stage (χ2=7.096, P=0.008), lymph node metastasis (χ2=5.893, P=0.015) and distant metastasis (P=0.003). Both with other factors had no significant correlation (P>0.05). IGF1R expression and IGFBP3 expression showed a negative correlation (r=-0.245, P=0.03). ConclusionThe over expression of IGF1R and low expression of IGFBP3 are associated with TNM stage and lymph node metastasis in colon cancer. IGF1R and IGFBP3 may become new targets of the treatment of colon cancer.

Key words: Colon cancer, Receptor, IGF type 1, Insulinlike growth factor binding protein 3, Immunohistochemistry