国际肿瘤学杂志

国际肿瘤学杂志 ›› 2019, Vol. 46 ›› Issue (6): 374-377.doi: 10.3760/cma.j.issn.1673-422X.2019.06.013

• 综述 • 上一篇    下一篇

节拍化疗在晚期非小细胞肺癌治疗中的应用

祝情情,谢超,宋宝,张秋景,刘杰   

  1. 1济南大学 山东省医学科学院医学与生命科学学院250022； 2山东大学附属山东省肿瘤医院肿瘤内科 山东省医学科学院，济南250117； 3山东大学附属山东省肿瘤医院基础实验室 山东省医学科学院，济南250117
  • 出版日期:2019-06-08 发布日期:2019-07-11
  • 通讯作者: 通信作者：刘杰，Email: lj691012@126.com E-mail:lj691012@126.com

Application of metronomic chemotherapy in the treatment of advanced nonsmall cell lung cancer

Zhu Qingqing1,2, Xie Chao2, Song Bao3, Zhang Qiujing1,2, Liu Jie2   

  1. 1School of Medicine and Life Sciences, University of JinanShandong Academy of Medical Sciences, Jinan 250022, China; 2Department of Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan 250117, China; 3Basic Laboratory, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan 250117, China
  • Online:2019-06-08 Published:2019-07-11
  • Contact: Liu Jie, Email: lj691012@126.com E-mail:lj691012@126.com

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摘要： 节拍化疗是一类全新多靶点的化疗模式。与传统化疗完全不同，节拍化疗通过细胞毒作用、抗血管生成、免疫调节等多重作用机制发挥协同持久的抗肿瘤作用。口服长春瑞滨节拍化疗单药及其联合治疗模式在晚期非小细胞肺癌治疗中具有良好的疗效及安全性。随着对节拍化疗的深入了解，节拍化疗必将成为晚期非小细胞肺癌的重要治疗模式。

关键词: 癌, 非小细胞肺, 化放疗, 药物疗法, 联合, 节拍化疗, 长春瑞滨

Abstract: Metronomic chemotherapy is a brandnew and multitarget chemotherapy strategy. Totally different from the traditional chemotherapy, metronomic chemotherapy can exert synergistic and durable antitumor effects via multiple mechanisms, including cytotoxic effect, antiangiogenesis, immune regulation and so on. Single and combined therapy modes of metronomic oral vinorelbine have good curative effects and safeties for the treatment of advanced nonsmall cell lung cancer. With the indepth understanding of metronomic chemotherapy, it will certainly become an important treatment mode for advanced nonsmall cell lung cancer.

Key words: Carcinoma, non-small-cell lung, Chemoradiotherapy, Drug therapy, combination, Metronomic chemotherapy, Vinorelbine