肺癌外周血VEGFC及VEGFR3检测的临床价值

doi:10.3760/cma.j.issn.1673-422X.2017.04.005

摘要/Abstract

摘要： 目的探讨肺癌患者外周血血管内皮生长因子C（VEGF-C）及血管内皮生长因子受体3（VEGF-R3）的表达及其与临床病理特征的关系，并评价其评估淋巴及血行转移的能力。方法采集124例肺癌患者、30例正常对照外周血，采用酶联免疫吸附试验（ELISA）进行VEGF-C及VEGF-R3的定量检测，分析其与肺癌临床病理特征的关系。结果肺癌患者血清VEGF-C及VEGF-R3的中位数（四分位数间距）分别为283.57（120.70）pg/ml、62.72（43.02）ng/ml，明显高于正常对照组的234.62（129.20）pg/ml、43.08（17.07）ng/ml（Z=-2.840，P=0.005；Z=-3.834，P＜0.001）。VEGF-C的表达与患者年龄、性别、原发灶部位及T分期均无关（Z=-0.949，P=0.343；Z=-0.454，P=0.649；Z=-1.168，P=0.243；Z=-1.694，P=0.090），与病理类型、N分期、M分期显著相关（χ2=8.829，P=0.012；χ2=27.148，P＜0.001；Z=-2.221，P=0.026）。而VEGF-R3的表达与患者年龄、性别、原发灶部位、病理类型及T、N、M分期均无关（Z=-0.558，P=0.577；Z=-0.599，P=0.549；Z=-0.703，P=0.482；χ2=1.166，P=0.558；Z=-0.680，P=0.496；χ2=0.353，P=0.950；Z=-1.523，P=0.128）。结论肺癌患者血清VEGF-C、VEGF-R3的表达水平均高于正常对照组，VEGF-C的表达与患者病理类型、N分期、M分期相关。外周血VEGF-C的检测有望成为辅助评估肺癌淋巴结及远处转移的肿瘤标志物，而VEGFR3尚未显示出该价值。

关键词: 肺肿瘤, 血管内皮生长因子C, 血管内皮生长因子受体3, 肿瘤转移

Abstract: Objective To investigate the relationship between the expression of vascular endothelial growth factor C (VEGF-C) and vascular endothelial growth factor receptor-3 (VEGF-R3) in peripheral blood of patients with lung cancer and the pathological characteristics, and to assess the ability to evaluate lymphatic and distant metastasis of the two marks. Methods VEGF-C and VEGF-R3 were detected by enzymelinked immunosorbent assay (ELISA) in 124 patients with lung cancer and 30 normal controls, and used to analyze the relationship with the pathological characteristics of lung cancer. Results The serum levels ［M(QR)］ of VEGF-C and VEGF-R3 in patients with lung cancer were 283.57 (120.70) pg/ml and 62.72 (43.02) ng/ml, significantly higher than the control whose VEGF-C and VEGF-R3 were 234.62 (129.20) ng/ml and 43.08 (17.07) pg/ml, respectively (Z=-2.840, P=0.005; Z=-3.834, P＜0.001). No correlation was found between the expression of VEGF-C and age, sex, primary tumor site, T stage (Z=-0.949, P=0.343; Z=-0.454, P=0.649; Z=-1.168, P=0.243; Z=-1.694, P=0. 090). But the expression of VEGF-C was significantly related with pathologic type, N stage and M stage (χ2=8.829, P=0.012; χ2=27.148, P＜0.001; Z=-2.221, P=0.026). However, the expression of VEGF-R3 was not correlated with age, sex, the site of the primary lesion, pathological type and T, N, M stage (Z=-0.558, P=0.577; Z=-0.599, P=0.549; Z=-0.703, P=0.482; χ2=1.166, P=0.558; Z=-0.680, P=0.496; χ2=0.353, P=0.950; Z=-1.523, P=0.128). Conclusion The expressions of VEGF-C and VEGF-R3 in patients with lung cancer are higher than those in normal control, and the expression of VEGF-C is related with pathologic type, N stage and M stage. The detection of VEGF-C in peripheral blood of lung cancer is expected to be an assistant marker for the evaluation of lymph node metastasis and blood metastasis, but VEGFR3 does not show its value.

Key words: Lung neoplasms, Vascular endothelial growth factor C, Vascular endothelial growth factor receptor-3, Neoplasm metastasis

姚月娟,王艳,王星,荆结线. 肺癌外周血VEGFC及VEGFR3检测的临床价值[J]. 国际肿瘤学杂志, 2017, 44(4): 262-265.

Yao Yuejuan, Wang Yan, Wang Xing, Jing Jiexian. Clinical value of the VEGF-C and VEGF-R3 in peripheral blood of patients with lung cancer[J]. Journal of International Oncology, 2017, 44(4): 262-265.

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