国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (1): 75-77.doi: 10.3760/cma.j.issn.1673-422X.2017.01.020

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微小RNA-32在肝细胞癌中的作用

姜晓佳,李胜棉   

  1. 050011 石家庄，河北医科大学第四医院消化内科
  • 出版日期:2017-01-08 发布日期:2016-12-07
  • 通讯作者: 李胜棉，Email: shengmianli2013@163.com E-mail:shengmianli2013@163.com

The role of microRNA-32 in hepatocarcinoma

Jiang Xiaojia, Li Shengmian   

  1. Department of Gastroenterology, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
  • Online:2017-01-08 Published:2016-12-07
  • Contact: Li Shengmian, Email: shengmianli2013@163.com E-mail:shengmianli2013@163.com

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被引次数

2

摘要： 微小RNA（miRNA）参与多种重要的细胞生物学过程，还参与包括肝细胞癌（HCC）在内的多种疾病的发生与发展。近年来研究发现miR-32在多种肿瘤组织中表达异常，miR-32在HCC中表达上调，扮演了“致癌基因”的角色，参与调控体内HCC细胞的细胞周期、凋亡及侵袭转移等多个病理生理过程，并有望成为HCC治疗的新靶点。

关键词: 肝肿瘤, 微RNAs, 微小RNA-32

Abstract: MicroRNAs （miRNA） play an important role in a variety of cellular biology processes, and participate in the occurrence and development of a variety of diseases including hepatocellular carcinoma (HCC). In recent years, miR-32 has been shown to be aberrantly expressed in many tumor tissues. miR-32 is up-regulated in HCC and plays an oncogene role in regulating the cell cycle, apoptosis, invasion, metastasis and so on. MiR-32 maybe a potential target for HCC therapy.

Key words: Liver neoplasms, MicroRNAs, MicroRNA-32