国际肿瘤学杂志

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (10): 733-736.doi: 10.3760/cma.j.issn.1673-422X.2016.10.003

• 论著 • 上一篇    下一篇

Ki-67和AR在三阴性乳腺癌中的表达及与复发的关系

杨文丽,彭雨,申旺,邓星辉,李荣岗,刘琼茹   

  1. 529030 中山大学附属江门医院病理科（杨文丽、邓星辉、李荣岗、刘琼茹），肿瘤科（彭雨）；广东省江门市五邑中医院检验科（申旺）
  • 出版日期:2016-10-08 发布日期:2016-09-07
  • 通讯作者: 杨文丽 E-mail:yangwenli902@163.com

Ki-67 and AR expression and its relationship with recurrence in triplenegative breast cancer

Yang Wenli, Peng Yu, Shen Wang, Deng Xinghui, Li Ronggang, Liu Qiongru   

  1. Department of Pathology Laboratory, Jiangmen Hospital Affiliated to Sun Yatsen University, Jiangmen 529030, China
  • Online:2016-10-08 Published:2016-09-07
  • Contact: Yang Wenli E-mail:yangwenli902@163.com

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摘要： 目的探讨增殖细胞抗原（Ki67）和雄激素受体（AR）在三阴性乳腺癌（TNBC）的表达及其与术后复发之间的关系。方法回顾性分析中山大学附属江门医院2006年1月至2010年12月66例TNBC和215例非三阴性乳腺癌（NTNBC）病理标本，采用免疫组织化学法检测Ki67和AR在其组织中的表达情况，并通过随访分析TNBC复发与Ki67和AR表达之间的关系，结果采用SPSS 19.0进行统计分析。结果TNBC组织中Ki67阳性率为75.76%(50/66)，明显高于其在NTNBC组织中的阳性率62.33%（134/215,χ2=4.031，P=0.045）；TNBC组织中AR阳性率为31.82%(21/66)，明显低于其在NTNBC组织中的阳性率76.28%（164/215,χ2=44.382，P＜0.001）。TNBC组织中Ki67的表达与组织学分级（χ2=6.031,P=0.049）、肿瘤直径（χ2=6.630，P=0.036）、淋巴节状态（χ2=5.440，P=0.020）有关；AR的表达与绝经状态（χ2=5.341,P=0.021）、体重指数（χ2=4.369，P=0.037）相关。TNBC术后复发与Ki67的表达有关（χ2=4.125，P=0.042），与AR表达无关（χ2=1.257，P=0.262）。结论Ki67的高表达和AR的低表达在TNBC中具有明显特征，Ki67阳性患者更易复发，可作为预测TNBC术后复发的指标。

关键词: 乳腺肿瘤, 免疫组织化学, 复发

Abstract: ObjectiveTo investigate the expressions of cellular proliferative antigen (Ki67) and androgen receptor (AR) in triplenegative breast cancer (TNBC) and their relationships with recurrence. MethodsSixtysix cases of TNBC and two hundred and fifteen cases of non triplenegative breast cancer (NTNBC) tissues between January 2006 and December 2010 in Jiangmen Hospital Affiliated to Sun Yatsen University were collected, the expressions of Ki67 and AR were detected by immunohistochemical, and through followup the relationships between TNBC recurrence and the expressions of Ki67 and AR were analyzed. SPSS 19.0 was used to analyze the results. ResultsThe positive rate of Ki67 in TNBC (75.76%, 50/66) was significantly higher than that in NTNBC (62.33%, 134/215, χ2=4.031, P=0.045), and Ki67 expression was correlated with histological grade (χ2=6.031, P=0.049), tumor diameter (χ2=6.630, P=0.036) and lymph node metastasis (χ2=5.440, P=0.020). The positive rate of AR in TNBC (31.82%, 21/66) was significantly lower than that in NTNBC (76.28%, 164/215, χ2=44.382, P＜0.001), and AR expression was correlated with menopausal status (χ2=5.341, P=0.021) and body mass index (χ2=4.369, P=0.037). TNBC recurrence was related to Ki67 expression (χ2=4.125, P=0.042), and was not related to AR expression (χ2=1.257, P=0.262). ConclusionHigh expression level of Ki67 and low expression level of AR are characteristics of TNBC. Ki67 positive patients are more likely to relapse, and it can be used as an indicator to predict TNBC recurrence.