微小RNA与肝癌复发

doi:10.3760/cma.j.issn.1673-422X.2015.10.018

摘要/Abstract

摘要： 微小RNA（miRNA）通过对目的基因翻译的调节，在肝癌复发的各机制中起重要作用。研究显示miRNA的异常表达与肝癌的复发密切相关，机制包括调控肿瘤血管生成和肿瘤细胞增殖等。miRNA可能成为最具潜力的肝癌治疗靶点，并在复发预测方面具有独特优势。

关键词: 微RNAs, 肝肿瘤, 复发

Abstract: microRNAs (miRNAs) play important roles in recurrent hepatocellular carcinoma by regulating translation of target gene expression. Researches show that the abnormal expressions of miRNAs are closely related to the recurrent hepatocellular carcinoma, and the mechanisms include regulation of tumor angiogenesis and proliferation of tumor cells. miRNAs may be the most potential therapeutic targets for recurrent hepatocellular carcinoma and have special advantages in prediction.

Key words: MicroRNAs, Liver neoplasms, Recurrence

马晨阳,胡明华. 微小RNA与肝癌复发[J]. 国际肿瘤学杂志, 2015, 42(10): 783-785.

Ma Chenyang, Hu Minghua. microRNAs and recurrent hepatocellular carcinoma[J]. Journal of International Oncology, 2015, 42(10): 783-785.

参考文献

［1］ Schoof CR, Botelho EL, Izzotti A, et al. MicroRNAs in cancer treatment and prognosis［J］. Am J Cancer Res, 2012, 2(4): 414-433. ［2］ Lanford RE, HildebrandtEriksen ES, Petri A, et al. Therapeutic silencing of microRNA122 in primates with chronic hepatitis C virus infection［J］. Science, 2010, 327(5962): 198-201. ［3］ Thibault PA, Huys A, Dhillon P, et al. MicroRNA122dependent and independent replication of Hepatitis C Virus in Hep3B human hepatoma cells［J］. Virology, 2013, 436(1): 179-190. ［4］ Qiu L, Fan H, Jin W, et al. miR-122induced down-regulation of HO-1 negatively affects miR-122mediated suppression of HBV［J］. Biochem Biophys Res Commun, 2010, 398(4): 771-777. ［5］ Wang S, Qiu L, Yan X, et al. Loss of microRNA-122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G(1) -modulated P53 activity［J］. Hepatology, 2012, 55(3): 730-741. ［6］ Roderburg C, Urban GW, Bettermann K, et al. MicroRNA profiling reveals a role for miR-29 in human and murine liver fibrosis［J］. Hepatology, 2011, 53(1): 209-218. ［7］ Jung CJ, Iyengar S, Blahnik KR, et al. Human ESC selfrenewal promoting microRNAs induce epithelialmesenchymal transition in hepatocytes by controlling the PTEN and TGFβ tumor suppressor signaling pathways［J］. Mol Cancer Res, 2012, 10(7): 979-991. ［8］ Venugopal SK, Jiang J, Kim TH, et al. Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation［J］. Am J Physiol Gastrointest Liver Physiol, 2010, 298(1): G101-G106. ［9］ Toffanin S, Sia D, Villanueva A. microRNAs: new ways to block tumor angiogenesis?［J］. J Hepatol, 2012, 57(3): 490-491. ［10］ Yang X, Zhang XF, Lu X, et al. MicroRNA26a suppresses angiogenesis in human hepatocellular carcinoma by targeting hepatocyte growth factorcMet pathway［J］. Hepatology, 2014, 59(5): 1874-1885. ［11］ Shih TC, Tien YJ, Wen CJ, et al. MicroRNA-214 downregulation contributes to tumor angiogenesis by inducing secretion of the hepatomaderived growth factor in human hepatoma［J］. J Hepatol, 2012, 57(3): 584-591. ［12］ Wang R, Zhao N, Li S, et al. MicroRNA-195 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting the expression of VEGF, VAV2, and CDC42［J］. Hepatology, 2013, 58(2): 642-653. ［13］ Fang JH, Zhou HC, Zeng C, et al. MicroRNA-29b suppresses tumor angiogenesis, invasion, and metastasis by regulating matrix metalloproteinase 2 expression［J］. Hepatology, 2011, 54(5): 1729-1740. ［14］ Xia H, Ooi LL, Hui KM. MiR-214 targets β-catenin pathway to suppress invasion, stemlike traits and recurrence of human hepatocellular carcinoma［J］. PLoS One, 2012, 7(9): e44206. ［15］ Xia H, Ooi LL, Hui KM. MicroRNA-216a/217induced epithelialmesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer［J］. Hepatology, 2013, 58(2): 629-641. ［16］ Yang Z, Miao R, Li G, et al. Identification of recurrence related microRNAs in hepatocellular carcinoma after surgical resection［J］. Int J Mol Sci, 2013, 14(1): 1105-1118. ［17］ Chung GE, Yoon JH, Myung SJ, et al. High expression of microRNA-15b predicts a low risk of tumor recurrence following curative resection of hepatocellular carcinoma［J］. Oncol Rep, 2010, 23(1): 113-119. ［18］ Utsunomiya T, Ishikawa D, Asanoma M, et al. Specific miRNA expression profiles of nontumor liver tissue predict a risk for recurrence of hepatocellular carcinoma［J］. Hepatol Res, 2014, 44(6): 631-638. ［19］ Sato F, Hatano E, Kitamura K, et al. MicroRNA profile predicts recurrence after resection in patients with hepatocellular carcinoma within the Milan Criteria［J］. PLoS One, 2011, 6(1): e16435. ［20］ Zhu HT, Dong QZ, Sheng YY, et al. MicroRNA-29a5p is a novel predictor for early recurrence of hepatitis B virusrelated hepatocellular carcinoma after surgical resection［J］. PLoS One, 2012, 7(12): e52393. ［21］ Xiong Y, Fang JH, Yun JP, et al. Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma［J］. Hepatology, 2010, 51(3): 836-845.

[1]	陈红健, 张素青. 血清miR-24-3p、H2AFX与肝癌患者临床病理特征及术后复发的关系研究[J]. 国际肿瘤学杂志, 2024, 51(6): 344-349.
[2]	刘萍萍, 何学芳, 张翼, 杨旭, 张珊珊, 季一飞. 原发性脑胶质瘤患者术后复发危险因素及预测模型构建[J]. 国际肿瘤学杂志, 2024, 51(4): 193-197.
[3]	彭琴, 蔡玉婷, 王伟. KPNA2在肝癌中的研究进展[J]. 国际肿瘤学杂志, 2024, 51(3): 181-185.
[4]	龚艳, 陈洪雷. 微RNA调控卵巢癌顺铂耐药的机制研究进展[J]. 国际肿瘤学杂志, 2024, 51(3): 186-190.
[5]	孙国宝, 杨倩, 庄庆春, 高斌斌, 孙晓刚, 宋伟, 沙丹. 结直肠癌肝转移组织病理学生长方式研究进展[J]. 国际肿瘤学杂志, 2024, 51(2): 114-118.
[6]	向玉玲, 谭佳杰, 熊远果, 赵丽蓉, 黎晨, 张洪. 脱水淫羊藿素对肝癌细胞增殖、迁移和凋亡的影响[J]. 国际肿瘤学杂志, 2023, 50(9): 513-519.
[7]	张露, 蒋华, 林州, 马辰莺, 徐晓婷, 王利利, 周菊英. 免疫检查点抑制剂治疗复发转移性宫颈癌的疗效及预后分析[J]. 国际肿瘤学杂志, 2023, 50(8): 475-483.
[8]	全祯豪, 徐飞鹏, 黄哲, 黄先进, 陈日红, 孙开裕, 胡旭, 林琳. 沉默lncRNA FTX通过miR-22-3p/NLRP3炎症体通路抑制胃癌细胞增殖[J]. 国际肿瘤学杂志, 2023, 50(4): 202-207.
[9]	杨丽蓉, 王羽丰. 预测浆液性卵巢癌术后复发远处转移风险机器学习模型的构建[J]. 国际肿瘤学杂志, 2023, 50(4): 220-226.
[10]	李佳璇, 封颖璐. 糖皮质激素受体在肝癌细胞生长中的作用机制[J]. 国际肿瘤学杂志, 2023, 50(4): 241-243.
[11]	马培晗, 张灵敏, 路宁, 张明鑫. 麻醉对肝细胞癌复发转移的影响[J]. 国际肿瘤学杂志, 2023, 50(2): 117-121.
[12]	段传菊, 陈真云, 李晓红, 牛洪朋, 李秀敏. 复发宫颈癌免疫治疗1例[J]. 国际肿瘤学杂志, 2023, 50(12): 766-768.
[13]	张露, 周菊英, 马辰莺, 林州. 复发转移性宫颈癌免疫治疗相关进展[J]. 国际肿瘤学杂志, 2022, 49(9): 517-520.
[14]	和婷, 王希, 张惠中, 刘昕阳, 王会平, 董轲. 血清TIM-3对肝癌患者诊断价值的研究[J]. 国际肿瘤学杂志, 2022, 49(9): 537-542.
[15]	吴浦嫄, 祁亮, 王涛, 史敏科, 孙雨薇, 王立峰, 刘宝瑞, 闫婧, 任伟. 基于高频复发区改良临床靶区的术后放疗在食管鳞状细胞癌中的疗效研究[J]. 国际肿瘤学杂志, 2022, 49(8): 464-472.