国际肿瘤学杂志

国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (4): 249-251.doi: 10.3760/cma.j.issn.1673-422X.2015.04.003

• 论著 • 上一篇    下一篇

三维适形放疗同步化疗治疗进展期食管癌的疗效观察

  

  1. 250012 济南，山东大学齐鲁医院放疗科
  • 出版日期:2015-04-08 发布日期:2015-04-22
  • 通讯作者: 程玉峰，Email:qlcyf@163.com

Effect of three dimensional conformal radiotherapy combined with chemotherapy for advanced esophageal carcinoma

  1. Department of Radiotherapy, Qilu Hospital of Shandong University, Jinan 250012, China  
  • Online:2015-04-08 Published:2015-04-22
  • Contact: Cheng Yufeng, Email: qlcyf@163.com

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被引次数

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摘要： 目的评价三维适形放疗同步化疗治疗进展期食管癌的近期疗效及不良反应。方法回顾性分析我科2008年1月至2011年1月的127例进展期食管鳞状细胞癌患者，分为同步放化疗组(69例)和单纯放疗组(58例)。观察两组的不良反应、生命质量及近期疗效。结果同步放化疗组白细胞下降和放射性食管炎的严重比例均明显高于单纯放疗组（29.0%∶12.1%，χ2=5.387，P=0.020；  24.6%∶10.3%，χ2=4.341，P=0.037）；生命质量，尤其是消化道不良反应（恶心、呕吐、腹泻）及进食量下降方面，同步放化疗组的患者的比例均明显高于单纯放疗组（73.9%∶12.1%，χ2=48.574，P=0.000； 43.5%∶25.9%，χ2=4.274，P=0.039）；同步放化疗组有效率91.30%，单纯放疗组72.41%，差异有统计学意义(χ2=7.852，P=0.005)。结论三维适形放疗同步化疗治疗进展期食管癌有较好的近期疗效，但不良反应也有所增加，长期疗效有待进一步观察。

关键词: 食管肿瘤, 放射疗法, 药物疗法

Abstract: ObjectiveTo evaluate the clinical efficacy and toxicities of three dimensional conformal radiotherapy combined with chemotherapy for advanced esophageal carcinoma. MethodsWe retrospectively reviewed 127 patients with advanced esophageal squamous carcinoma in our department from January 2008 to January 2011, who were divided into two groups: conformal radiotherapy combined with chemotherapy (RCT) group, 69 patients and radiotherapy(RT) group, 58 patients. The side effects, quality of life and effective rates of them were compared. ResultsThe severe rate of the marrow toxic effect and the incidences of radiationinduced esophagitis were higher in the RCT group (29.0%vs 12.1%，χ2=5.387, P=0.020; 24.6%vs10.3%，χ2=4.341, P=0.037)．Patients in the RT group had better quality of life than those in the RCT group in gastrointestinal side effects (nausea, vomiting, diarrhea) and food intake (73.9%vs 12.1%，χ2=48.574, P=0.000; 43.5%vs 25.9%， χ2=4.274, P=0.039). In the RCT group, the effective rate was 91.30% (63/69) and 72.41 % (42/58) in the RT group, with a statistical significance (χ2=7.852, P=0.005).  ConclusionThree dimensional conformal radiotherapy combined with chemotherapy for advanced esophageal carcinoma can improve the shortterm curative effects, but it also increase the acute toxic effect. Further followup studies are needed for its longterm effect.

Key words: Esophageal neoplasms, Radiotherapy, Drug therapy