国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (4): 244-247.doi: 10.3760/cma.j.issn.1673422X.2014.04.002

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TRIB3在未折叠蛋白反应中的作用

田少博,龙跃平   

  1. 430030 武汉，华中科技大学同济医学院附属协和医院普外科
  • 出版日期:2014-04-08 发布日期:2014-03-17
  • 通讯作者: 龙跃平 E-mail:longyueping85882@sina.com

Roles of TRIB3  in  unfolded  protein responseTian Shaobo

TIAN  Shao-Bo, LONG  Yue-Ping   

  1. Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  • Online:2014-04-08 Published:2014-03-17
  • Contact: Long Yueping E-mail:longyueping85882@sina.com

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被引次数

1

摘要： 肿瘤细胞的内质网应激非常普遍，内质网内大量未折叠或错误折叠的蛋白质蓄积可诱发未折叠蛋白反应（UPR）。研究表明，初期UPR可保护细胞，恢复内质网功能和内环境稳态，后期则促进细胞凋亡。TRIB3是哺乳动物假性蛋白激酶家族Tribbles中的一员，其在UPR中起重要的枢纽作用，既能促进肿瘤细胞凋亡又可起保护作用。

关键词: 肿瘤, 内质网, TRIB3, 未折叠蛋白反应

Abstract: Endoplasmic reticulum stress in tumor cells is common, the  accumulation of unfolded or misfolded proteins in the endoplasmic reticulum can lead to unfolded protein response (UPR). Research shows that UPR can protect cells,  reestablish endoplasmic reticulum function and homeostasis at initial stage, and can promote apoptotic at later stage. TRIB3 is one of the mammal pseudoprotein kinase family Tribbles, and plays an important pivotal role in UPR, which can not only promote apoptosis but also play a protective role.

Key words: Neoplasms, Endoplasmic reticulum, TRIB3, Unfolded  , protein response