Abstract: Forkhead box A1 (FOXA1) is expressed in various organs, including breast, liver, pancreas, bladder, prostate, colon, ovary, lung and esophagus. The FOXA1 expression is associated with the growth and carcinogenesis of these organs. It is recently demonstrated FOXA1 plays a significant role in different biological processes including cell proliferation,differentiation,devolopment,carcinogenesis and the process of epithelialmesenchymal transition (EMT)etc. Its expression is positively correlated with ER and PR expression, and it is demonstrate to be one of the most important favorate prognostic factors of breast cancer.