Journal of International Oncology ›› 2015, Vol. 42 ›› Issue (5): 358-360.doi: 10.3760/cma.j.issn.1673422X.2015.05.010

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Research update on PD1 and its ligand PDL1 in malignant tumor

  

  1. Department of Oncology, First Affiliated Hospital of Anhui Medical University
  • Online:2015-05-08 Published:2015-05-12
  • Contact: Sun Guoping sunguoping@ahmu.edu.cn

Abstract: Programmed death1ligand(PDL1) is a new member of B7 family,whose  receptor  is programmed death1(PD1). The interaction between PDL1 and PD1 can downregulate the activation of immune response.There are some differences in the expression of  PD1 and PDL1 in normal tissues and tumor tissues, which may provide a new way for the immunotherapy of carcinoma.