Abstract: As an important member of the adisintegrin and metalloproteinase（ADAM） superfamily, ADAM17 can mediate a variety of membrane molecular hydrolysis off, such as adhesion molecules, cytokines, growth factors, etc, and play an important role in regulating tumor cell adhesion, apoptosis, metastasis and proliferation through the EGFRPI3KAkt pathway, Notch signaling pathway and other signaling pathways. The research of ADAM17 targeted drugs provides a new direction for cancer therapy.

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