Abstract: Conformal radiotherapy is an important therapeutic strategy for primary hepatic carcinoma, which has high local control rate. However, the frequency of intra- and extra-epatic recurrences is very high. Sorafenib is the only drug that has been demonstrated effectiveness to increase overall survival in advanced or metastatic hepatocellular carcinoma. The combination about radiotherapy and sorafenib can increase the radiosensitiveness，and inhibit the angiogenesis，and relieve the hypoxia, as well as synchronize the cell cycle. A lot of biological studies of sorafenib combined with radiotherapy have been carried out, and the phase Ⅰ-Ⅱclinical trials are is in progress.

Key words: Radiotherapy, Liver neoplasms, Sorafenib