Abstract: Phosphatase of regenerating liver-3 (PRL-3) is a novel small molecule proteintyrosinephosphatase, which plays an important role in the  oncogenesis and deveopment of tumors. Studies show that PRL-3 regulates neoplasm progress through participating in multiple signal pathways. Its high expression can significantly promote neoplasm metastasis in cancer tissue. However, there is no expression of PRL-3 in most normal tissue. PRL-3 is expected to be a potential tumor maker of diagnosis and a new target for the therapy of cancer. 

Key words: Protein tyrosine phosphatases, Neoplasm, Signal transduction, Tyrphostins