SIRT1 and neoplasms.

Abstract

Abstract: SIRT1 (Sirtuin type 1) is dependent on nicotinamide adenine dinucleotide (NAD +) group Protein deacetylase involved in the covalent modification of histones, participated in tumor development and progression through transcription, translation and post-translational modification and so on. Therefore， the expression of SIRT1 in tumor cells or abnormal function could be one of the important mechanisms of tumor development，and may become a new potential therapeutic targets for cancer

Key words: SIRT1, neoplasms, Target therapy

GUO Shu-Qin, ZHU Chun-Ying, ZHANG Yun-Liang. SIRT1 and neoplasms.[J]. Journal of International Oncology, 2011, 38(8): 569-571.

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SIRT1 and neoplasms.

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