Abstract: Mucosal malignant melanoma of the head and neck is one of the rarely malignant diseases, The standard therapy for mucosal melanoma of the head and neck continues to be radical surgery, possibly associated with adjuvant radiation. The immunotherapy and chemotherapeutics confirmed existence certain curative effect, Molecular staging and targeted therapy may will be the new tendency in future.

Key words: Mucosal melanoma of the head and neck, radical surgery, radiotherapy,