Research progress of molecular targeted therapy of ROS1 gene mutation in non-small cell lung cancer

doi:10.3760/cma.j.cn371439-20250810-00016

Abstract

Abstract:

The incidence of ROS1 gene rearrangement in non-small cell lung cancer （NSCLC） is 1%-2%. It is involved in the proliferation， metastasis and invasion of NSCLC cells. The advent of ROS1-tyrosine kinase inhibitors （TKIs） has significantly improved the prognosis of ROS1 gene mutant NSCLC patients. However， most patients have acquired resistance after continuous drug use， which seriously challenges the therapeutic effect of tumor targeted drugs. The molecular resistance mechanism of ROS1-TKIs is not completely understood. Further exploration of the background， mutation mode， ROS1-TKIs and resistance mechanism of ROS1 fusion gene can provide new treatment ideas for NSCLC patients resistant to ROS1-TKIs.

Key words: Carcinoma， non-small-cell lung, Molecular targeted therapy, Drug resistance， neoplasm, ROS proto-oncogene 1, Therapeutics

Zhao Yue, Song Chenchen, Liang Tianci, Wang Hui, Wen Tingzhi, Rong Biaoxue. Research progress of molecular targeted therapy of ROS1 gene mutation in non-small cell lung cancer[J]. Journal of International Oncology, 2026, 53(2): 105-110.

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