Research progress in reversing multidrug resistance in colorectal cancer

doi:10.3760/cma.j.cn371439-20220614-00008

Abstract

Abstract:

Multidrug resistance impacts negatively upon the curative effect of chemotherapy and prognosis in colorectal cancer. There is a growing body of studies trying to develop drugs to overcome multidrug resistance against its common targets， including ATP-binding cassette proteins， metabolic enzymes， apoptotic genes， signaling pathways and genetic material， among which P-glycoprotein inhibitors and drugs disrupting DNA are deeply developed. Developing new inhibitors or combining existing inhibitors with conventional treatment are hopeful ways to overcome multidrug resistance in colorectal cancer.

Key words: Colorectal neoplasms, Drug resistance， neoplasm

Wang Xi, Wu Chuanqing. Research progress in reversing multidrug resistance in colorectal cancer[J]. Journal of International Oncology, 2023, 50(1): 42-46.

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