Research progress on the mechanism of bone marrow suppression after chemotherapy

doi:10.3760/cma.j.cn371439-20221005-00006

Abstract

Abstract:

As an effective treatment for cancer， chemotherapy not only removes tumor cells， but also produces obvious killing effects on proliferating cells， especially hematopoietic cells， resulting in bone marrow suppression after chemotherapy， and affecting the effects of chemotherapy drug treatment and treatment cycle. Therefore， starting from the aspects of hematopoietic microenvironment damage and hematopoietic stem cell aging， to explore the mechanism of myelosuppression after chemotherapy， which provides new ideas and theoretical support for the intervention and management of bone marrow suppression after cancer chemotherapy.

Key words: Hematopoietic stem cells, Cellular senescence, Myelosuppression, Chemotherapy, Hematopoietic microenvironment

Sun Qi, Li Wenqian, Xie Youbang, Zhou Houfa. Research progress on the mechanism of bone marrow suppression after chemotherapy[J]. Journal of International Oncology, 2023, 50(1): 33-36.

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