Journal of International Oncology ›› 2022, Vol. 49 ›› Issue (8): 459-463.doi: 10.3760/cma.j.cn371439-20220408-00089

• Original Articles • Previous Articles     Next Articles

Comparative study on the clinical value of contrast-enhanced ultrasound- and CT-guided percutaneous puncture biopsy in peripheral lung masses

Chen Huangjing, Zhu Pengfei, Zhang Qing, Chen Guifang, Yang Chunlin, He Ying()   

  1. Department of Ultrasound, Tumor Hospital Affiliated to Nantong University, Nantong 226361, China
  • Received:2022-04-08 Revised:2022-06-15 Online:2022-08-08 Published:2022-09-21
  • Contact: He Ying E-mail:heying168@sina.com
  • Supported by:
    Nantong Science and Technology Project(MS12018086);Scientific Research Project Financed by Nantong “226 Talent Project”

Abstract:

Objective To compare the clinical value of contrast-enhanced ultrasound (CEUS)- and CT-guided percutaneous puncture biopsy in the diagnosis of peripheral lung masses. Methods The clinical data of 90 patients with peripheral lung masses who underwent puncture biopsy in Tumor Hospital Affiliated to Nantong University from October 2019 to December 2021 were retrospectively analyzed. According to different puncture guidance methods, patients were divided into CEUS-guided percutaneous puncture biopsy group (CEUS group, n=40) and the CT-guided percutaneous puncture biopsy group (CT group, n=50), and the differences in puncture success rates, complication rates and other factors between the two groups were evaluated. Meanwhile, the correlations between microvascular density (MVD) and CEUS parameters were detected. Results The puncture success rate in the CEUS group was higher than that in the CT group, but there was no statistically significant difference [97.5%(39/40) vs. 92.0%(46/50), P=0.337], and the complication rate in the CEUS group was significantly lower than that in the CT group [0(0/40) vs. 12.0%(6/50), P=0.032]. Compared with the CT group, the CEUS group has fewer punctures [(2.0±1.6) times vs. (2.8±1.2) times, t=-2.43, P=0.018], shorter duration [(7.6±2.5) min vs. (15.3±2.6) min, t=-8.86, P<0.001] and lower cost of surgery [(1 308.4±545.6) yuan vs. (2 046.4±645.3) yuan, t=-2.01, P=0.046]. The MVD, CEUS peak intensity and enhancement index of lung adenocarcinoma were higher than those of squamous cell carcinoma [(25.4±4.9)/HP) vs. (16.6±7.3)/HP, t=3.43, P=0.002; (46.9±6.5)db vs. (36.8±5.4)db, t=4.12, P<0.001; 5.2±1.4 vs. 4.1±1.2, t=3.27, P=0.006]. The peak intensity and intensity index of CEUS in lung adenocarcinoma or squamous cell carcinoma were positively correlated with itself MVD (squamous cell carcinoma: r=0.66, P<0.001; r=0.56, P<0.001; adenocarcinoma: r=0.62, P<0.001; r=0.70, P<0.001). Conclusion Although CEUS-guided percutaneous puncture biopsy does not achieve a higher puncture success rate in the diagnosis of peripheral lung masses compared to CT, it really decreases the complication rate, and has the advantages of less time, low cost, no radiation and real-time dynamic monitoring, which is worth promoting in clinic. Moreover, there are correlations between CEUS quantitative parameters of adenocarcinoma and squamous cell carcinoma of the lung and MVD, which may be useful for diagnosis.

Key words: Lung neoplasms, Contrast-enhanced ultrasound, Percutaneous lung aspiration biopsy, Pathological diagnosis, Microvascular density