Role of JAK2-STAT3 signaling pathway in tumorigenesis and development

doi:10.3760/cma.j.cn371439-20210428-00146

Abstract

Abstract:

JAK2-STAT3 signaling pathway, as the main chain of intracellular signal transmission, plays an important role in cell proliferation, apoptosis, invasion, migration and immune response. Triggered by cytokines and interferon, this pathway can quickly transduce extracellular signals into the nucleus, and it has abnormal expression in various tumors, such as squamous cell carcinoma of the head and neck, lung cancer, esophageal cancer, gastric cancer, liver cancer, breast cancer and myeloproliferative neoplasms. Further understanding of the carcinogenic mechanism of JAK2-STAT3 signaling pathway can provide new ideas for clinical treatment of tumors and prognosis.

Key words: Neoplasms, JAK2-STAT3 signaling pathway

Luo Pan, Zeng Yan, Wu Weili. Role of JAK2-STAT3 signaling pathway in tumorigenesis and development[J]. Journal of International Oncology, 2021, 48(12): 739-742.

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