Human telomerase reverse transcriptase and cutaneous malignant tumor

doi:10.3760/cma.j.issn.1673-422X.2019.10.015

Journal of International Oncology ›› 2019, Vol. 46 ›› Issue (10): 634-637.doi: 10.3760/cma.j.issn.1673-422X.2019.10.015

Previous Articles Next Articles

Human telomerase reverse transcriptase and cutaneous malignant tumor

Zhao Juan1, Kang Xiaojing2

1Postgraduate College of Xinjiang Medical University, Urumqi 830054, China; 2Department of Dermatology, People′s Hospital of Xingjiang Uygur Autonomous Region, Urumqi 830001, China

Online:2019-10-08 Published:2019-12-22
Contact: Kang Xiaojing, Email: drkangxj666@163.com E-mail:drkangxj666@163.com
Supported by:
Natural Science Foundation of Xinjiang Uygur Autonomous Region of China (2016D01C101)

Abstract

Abstract:

Human telomerase reverse transcriptase (hTERT) is a catalytic subunit of telomerase and is closely related to immortalization of cells, tumorigenesis and senescence of cells. hTERT has a great relationship with the occurrence and development of skin malignant tumors (melanoma, squamous cell carcinoma, basal cell carcinoma, cutaneous lymphoma, etc.). Abnormal expression of hTERT has important clinical application value in early diagnosis, individualized comprehensive treatment and prognosis evaluation of cutaneous malignant tumors.

Key words:

Telomere, Skin neoplasms, Genes, Human telomerase reverse transcriptase

Zhao Juan, Kang Xiaojing.

Human telomerase reverse transcriptase and cutaneous malignant tumor [J]. Journal of International Oncology, 2019, 46(10): 634-637.

[1]	Guo Zehao, Zhang Junwang. Role of PFDN and its subunits in tumorigenesis and tumor development [J]. Journal of International Oncology, 2024, 51(6): 350-353.
[2]	Liu Xiaodi, Su Jianfei, Zhang Jingxian, Wei Xueqin, Jia Yingjie. Research progress of myeloid-derived suppressor cells in tumor angiogenesis [J]. Journal of International Oncology, 2024, 51(1): 50-54.
[3]	Ye Tongtong, Wu Zeyu, Xi Wenyi, Wang Zhiwei, Jiang Xiaochun, Zhao Chenhui. Role of ABRACL in the occurrence and development of malignant tumors [J]. Journal of International Oncology, 2023, 50(9): 544-547.
[4]	Pan Shulan, Liu Chang, He Ping. Effect of fritinib on angiogenesis, tumor growth and IRE1-ASK1-JNK pathway in triple negative breast cancer [J]. Journal of International Oncology, 2023, 50(8): 457-462.
[5]	Zhang Yuan, Bai Zhiyu, Li Qi, Feng Qinmei. Current status of research on exosomes in malignancies [J]. Journal of International Oncology, 2023, 50(8): 484-488.
[6]	Liu Yujie, Zhao Zhiqiang, Wang Zicheng. Levels and diagnostic value of TOP2A and ERBB2 in peripheral blood mononuclear cells of patients with early colorectal cancer [J]. Journal of International Oncology, 2023, 50(12): 717-722.
[7]	Deng Lili, Duan Xingyu, Li Baozhong. Advances of anti-HER2 targeted drugs and combined therapeutic regimens for gastric and esophagogastic adenocarcinoma [J]. Journal of International Oncology, 2023, 50(12): 751-757.
[8]	Li Lixi, Wen Tingyu, Guan Xiuwen, Zhai Jingtong, Ma Fei. Genetic susceptibility genes and clinical features of early-onset breast cancer [J]. Journal of International Oncology, 2022, 49(4): 206-209.
[9]	Yu Jiaojiao, Wang Jun, Wang Likang, Yao Nan. Advances in the amplification of HER2 in metastatic colorectal cancer [J]. Journal of International Oncology, 2021, 48(4): 246-249.
[10]	Zheng Jing, Yao Sheng, Shen Wenjie, Sun Zhijia, Zhao Hui, Fu Yan, Gao Ke, Du Nan. Clinical study of intraperitoneal infusion of bevacizumab combined with albumin paclitaxel and carboplatin in carcinomatous peritoneal adhesion from ovarian cancer [J]. Journal of International Oncology, 2021, 48(11): 660-665.
[11]	Sang Yingbing, Liang Junqin. Epigenetic pathogenesis of cutaneous squamous cell carcinoma [J]. Journal of International Oncology, 2020, 47(9): 569-572.
[12]	Ren Meng, Gao Yan, Chen Qi, Yue Wentao. Application of keratins in cancer diagnosis and prognosis [J]. Journal of International Oncology, 2020, 47(6): 360-363.
[13]	Zou Wenjing, He Shuixiang, Liu Dan, Li Xu. Screening differential genes and prognostic analysis of gastric cancer based on TCGA database [J]. Journal of International Oncology, 2020, 47(4): 211-216.
[14]	Zhao Chuanxi, Zhu Tingting, Liu Mingguo, Cao Lili. Advances of Krüppel-like factors in hepatocellular carcinoma [J]. Journal of International Oncology, 2020, 47(2): 119-122.
[15]	Song Mingze, Cheng Yiming, Li Gang, Wang Zhenming, Li Shirong. Value of P16/Ki-67 double staining detection in screening cervical cancer and precancerous lesions [J]. Journal of International Oncology, 2020, 47(11): 675-681.

Human telomerase reverse transcriptase and cutaneous malignant tumor

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments