Abstract: Beta 2-microglobulin (β2-MG) has low expression levels in tissues and cells of normal organisms, but its expression levels is increasing in tumor. The main function of β2-MG is to regulate signal transduction in tumor cells and promote tumor cell growth and angiogenesis. High level expression of β2-MG is associated with the occurrence, progression, metastasis and prognosis of human tumors and can serve as an independent indicator of tumor prognosis. It has been confirmed in a variety of tumor cells that agent targeting β2-MG is expected to become a new generation of targeted drugs.

Key words: Beta 2-microglobulin, Neoplasms, Prognosis