Mechanisms and translational prospects of tumor-derived exosomes in tumor bone metastasis

doi:10.3760/cma.j.cn371439-20260123-00091

Abstract

Abstract:

Tumor-derived exosome （TEX） serves as a core mediator of intercellular information transmission and exerts pivotal regulatory effects on the progression of bone metastasis in malignant tumors by delivering bioactive molecules，including microRNAs，proteins，and lipids. It not only mediate the directed homing of tumor cells to the bone tissue，but also participate in the remodeling of the bone pre-metastatic microenvironment，and further drive the vicious cycle of "tumor growth-bone destruction". Systematically elucidating the specific regulatory mechanisms of TEX in bone metastasis of malignant tumors，and exploring its clinical translational potential as an early diagnostic biomarker for bone metastasis，a therapeutic target，and a drug delivery carrier，can provide new strategies and directions for the precise diagnosis and treatment of malignant tumor bone metastasis.

Key words: Neoplasm metastasis, Exosomes, Tumor microenvironment

Zhang Jie, Chen Jinshu, Li Yuan, Lou Yanni, Liu Qing. Mechanisms and translational prospects of tumor-derived exosomes in tumor bone metastasis[J]. Journal of International Oncology, 2026, 53(9): 572-576.

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