Research progress on preoperative radiotherapy for breast cancer

doi:10.3760/cma.j.cn371439-20251112-00049

Abstract

Abstract:

Preoperative radiotherapy is an important development direction in the field of comprehensive treatment of breast cancer. Its clinical value lies not only in tumor downstaging and improving the pathological complete response rate， but also in optimizing the timing of breast reconstruction and reducing long-term complications. With the rapid advancement of precise radiotherapy and immunotherapy， increasing attention has been paid to the biological synergistic effects of preoperative radiotherapy in inducing immunogenic cell death and regulating the tumor microenvironment. This review provides an in-depth discussion of the clinical value， key technical models， and multidisciplinary joint strategies of preoperative radiotherapy for breast cancer， systematically summarizes the latest evidence， and delineates the key challenges， which may guide the clinical practice of preoperative radiotherapy in patients with breast cancer and improve patient prognosis.

Key words: Breast neoplasms, Radiotherapy, Pathological complete response

Li Lina, Liu Shuai, Zhang Nan. Research progress on preoperative radiotherapy for breast cancer[J]. Journal of International Oncology, 2026, 53(5): 301-305.

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