Abstract: Metronomic chemotherapy is a brandnew and multitarget chemotherapy strategy. Totally different from the traditional chemotherapy, metronomic chemotherapy can exert synergistic and durable antitumor effects via multiple mechanisms, including cytotoxic effect, antiangiogenesis, immune regulation and so on. Single and combined therapy modes of metronomic oral vinorelbine have good curative effects and safeties for the treatment of advanced nonsmall cell lung cancer. With the indepth understanding of metronomic chemotherapy, it will certainly become an important treatment mode for advanced nonsmall cell lung cancer.

Key words: Carcinoma, non-small-cell lung, Chemoradiotherapy, Drug therapy, combination, Metronomic chemotherapy, Vinorelbine