Application progress of high-dose furmonertinib in NSCLC with drug-resistant EGFR mutation

doi:10.3760/cma.j.cn371439-20250929-00079

Abstract

Abstract:

Furmonertinib， a third-generation epidermal growth factor receptor （EGFR） tyrosine kinase inhibitor independently developed in China， has demonstrated remarkable efficacy in the treatment of EGFR-mutant non-small cell lung cancer （NSCLC）， particularly offering significant advantages for patients with T790M resistance mutations and central nervous system metastases. High-dose furmonertinib （160-240 mg/d） has been used for NSCLC with resistance-related EGFR mutations such as P-cyclin-dependent kinase α-C helix compression mutations and soft meningeal metastases. Systematically elaborating on the application progress of high-dose furmonertinib in drug-resistant NSCLC can provide evidence-based support for optimizing the treatment strategies for refractory NSCLC.

Key words: Carcinoma, non-small-cell lung, Drug resistance, neoplasm, Genes, erbB-1, High dose, Furmonertinib

Zeng Jiao, Ding Jianghua. Application progress of high-dose furmonertinib in NSCLC with drug-resistant EGFR mutation[J]. Journal of International Oncology, 2026, 53(8): 491-495.

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