Research progress of anti-angiogenic agents in the treatment of adenocarcinoma of the esophagogastric junction and gastric cancer

doi:10.3760/cma.j.cn371439-20251231-00089

Abstract

Abstract:

Adenocarcinoma of the esophagogastric junction （AEG） and gastric cancer are common malignant tumors worldwide. Angiogenesis is a key mechanism in tumor development. Currently，anti-angiogenic therapy has become an important strategy for the treatment of AEG and gastric cancer. Anti-angiogenic drugs mainly include monoclonal antibodies （such as bevacizumab and ramucirumab） and small molecule tyrosine kinase inhibitors （such as apatinib，fruquintinib，regorafenib，lenvatinib，anlotinib，sorafenib，and cabozantinib），which can be used as single drugs or in combination for multi-line，neoadjuvant or conversion maintenance treatment of AEG and gastric cancer，and have shown certain survival benefits. An in-depth exploration of the research progress of anti-angiogenic drugs in the treatment of AEG and gastric cancer can provide references for optimizing clinical treatment strategies.

Key words: Stomach neoplasms, Adenocarcinoma, Esophagogastric junction, Angiogenesis inhibitors

Sun Jie, Liu Zhiqiang, Li Baozhong. Research progress of anti-angiogenic agents in the treatment of adenocarcinoma of the esophagogastric junction and gastric cancer[J]. Journal of International Oncology, 2026, 53(9): 559-565.

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