国际肿瘤学杂志

国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (1): 18-21.doi: 10.3760/cma.j.issn.1673-422X.2015.01.005

• 论著 • 上一篇    下一篇

B7-H1和Bcl-2在上皮性卵巢癌中表达及其临床意义

郝志强, 李晓凤, 于德东, 白雪峰   

  1. 014040包头市中心医院肿瘤科（郝志强、于德东）；包头医学院研究生学院（郝志强）；包头市肿瘤医院肿瘤综合内科（李晓凤），病理科（白雪峰）
  • 收稿日期:2014-06-08 修回日期:2014-08-27 出版日期:2015-01-08 发布日期:2015-01-07
  • 通讯作者: 李晓凤 E-mail:btlixiaofeng@126.com
  • 基金资助:

    包头市医药卫生科技计划(Wsjj2014031)

Expressions of B7-H1 and Bcl-2 in epithelial ovarian cancer and their clinical significance

Hao Zhiqiang, Li Xiaofeng, Yu Dedong, Bai Xuefeng   

  1. Department of Oncology, Baotou Central Hospital; College of Postgraduate, Baotou Medical College, Baotou 014040, China
  • Received:2014-06-08 Revised:2014-08-27 Online:2015-01-08 Published:2015-01-07
  • Contact: Li Xiaofeng E-mail:btlixiaofeng@126.com

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摘要： 目的 探讨B7-H1与Bcl-2在上皮性卵巢癌组织中的表达及其与上皮性卵巢癌临床病理特征之间的关系。方法应用免疫组织化学法检测手术切除的80例上皮性卵巢癌组织及20例正常卵巢组织蜡块中B7-H1及Bcl-2的表达情况，并分析其表达与不同临床病理特征之间的相关性。结果上皮性卵巢癌组织B7-H1及Bcl-2阳性表达率分别为77.5%（62/80）和58.8%（47/80），均高于正常卵巢组织的15.0%（3/20）和10.0%（2/20），差异有统计学意义（χ2=27.473，P＜0.05；χ2=15.216，P＜0.05）。Bcl2及B7-H1在上皮性卵巢癌组织中的表达均与分化程度呈负相关（χ2=9.367，P＜0.01；χ2=11.702，P＜0.01），而且Bcl2与国际妇产科联合会分期呈正相关（χ2=7.766，P＜0.01）。另外，在上皮性卵巢癌组织中B7-H1和Bcl-2阳性表达之间呈正相关（r=0.400，P＜0.01）。结论B7H1和Bcl2在上皮性卵巢癌组织中表达明显上调，二者存在正相关性，与上皮性卵巢癌的发生、发展有关，联合检测B7H1和Bcl2可能对上皮性卵巢癌的诊治有一定的指导作用。

关键词: 卵巢肿瘤, 基因, B7-H1, Bcl-2, 免疫组织化学

Abstract: ObjectiveTo investigate the expressions of B7-H1 and Bcl-2 proteins in epithelial ovarian cancer, and to explore the association of the expressions of B7-H1 and Bcl-2 with clinicopathological features. MethodsThe expressions of B7-H1 and Bcl-2 proteins were detected by immunohistochemistry in 80 cases of epithelial ovarian cancer tissues and 20 normal ovary tissues. The association of the expressions of B7H1 and Bcl2 with the clinicopathological features was analyzed. ResultsThe positive expression rates of B7H1 and Bcl2 in epithelial ovarian cancer tissues were 77.5% (62/80) and 58.8% (47/80), both higher than 15.0% (3/20) and 10.0% (2/20) in normal ovary tissues with significant difference （χ2=27.473, P＜0.05; χ2=15.216, P＜0.05）. Both of Bcl2 and B7H1 expressions in epithelial ovarian cancer tissues were negatively correlated with the differentiation degree of epithelial ovarian cancer (χ2=9.367， P＜0.01； χ2=11.702， P＜0.01). The Bcl-2 expression in epithelial ovarian cancer tissues was positively correlated with the FIGO stage (χ2=7.766, P＜0.01). The expression of B7-H1 was positively correlated with the expression of Bcl2 in epithelial ovarian cancer (r=0.400, P＜0.01). ConclusionThe expressions of B7-H1 and Bcl-2 are upregulated in epithelial ovarian cancer and they correlate to each other positively. The expressions of B7-H1 and Bcl-2 are correlated with the invasion and metastasis of epithelial ovarian cancer. The detection of B7-H1 combined with Bcl-2 may have an important clinical significance in the diagnosis and treatment for patients with epithelial ovarian cancer.

Key words: Ovarian neoplasms, Gene, B7-H1, Bcl-2, Immunohistochemistry