国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (1): 74-76.doi: 10.3760/cma.j.issn.1673-422X.2014.01.023

• 论著 • 上一篇    下一篇

斑蝥酸钠维生素B6注射液联合化疗治疗急性白血病的临床观察

吴贤义,林文远,农庆伟,唐荣芳,伍志梅   

  1. 541001 桂林医学院附属医院血液科
  • 出版日期:2014-01-08 发布日期:2014-01-22
  • 通讯作者: 林文远，E-mail: sanlidian@163.com E-mail:sanlidian@163.com

Clinical observation of sodium cantharidate vitamin B6 injection combined with chemotherapy for acute leukemia patients

Wu Xianyi, Lin Wenyuan, Nong Qingwei, Tang Rongfang, Wu Zhimei   

  1. Department of Hematology, Affiliated Hospital of Guilin Medical University, Guilin 541001, China
  • Online:2014-01-08 Published:2014-01-22
  • Contact: Lin Wenyuan E-mail:sanlidian@163.com

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被引次数

2

摘要： 目的 观察斑蝥酸钠维生素B6注射液联合化疗对急性白血病患者的疗效。方法 113例急性白血病患者按是否使用斑蝥酸钠维生素B6注射液分为试验组（81例）和对照组（32例），试验组给予标准化疗方案联合斑蝥酸钠维生素B6注射液进行治疗；对照组仅给予标准化疗方案治疗。观察对比两组患者的缓解情况、化疗后骨髓抑制情况、骨髓总体恢复时间及其他不良反应。结果 治疗后试验组中完全缓解（CR）39例（48.15%），部分缓解（PR）31例（38.27%），未缓解（NR）11例（13.58%），对照组中CR、PR和NR例数分别为10（31.25%）、10（31.25%）和12例（37.50%），试验组总体缓解率高于对照组（χ2=8.270，P=0.016）。按年龄分层比较，试验组的中、老年患者缓解率较对照组高（χ2=6.360，P=0.042；χ2=6.432，P=0.040），而青年组间差异无统计学意义（χ2=1.829，P=0.401）。按疾病分类，试验组急性髓系白血病（非M3型）缓解率较对照组高（ χ2=11.411，P=0.003），急性淋巴细胞白血病与对照组相比差异无统计学意义（ χ2=1.739，P=0.419）。试验组化疗后粒系及血小板的抑制程度均轻于对照组（Z=-2.142，P=0.032；Z=-2.490，P=0.013），而红系抑制程度间差异无统计学意义（Z=-0.483，P=0.629）。试验组总体骨髓恢复时间为（6.26±1.34） d，短于对照组的（11.33±2.18） d（t=-14.186，P=0.000）。结论 标准化疗方案联合斑蝥酸钠维生素B6注射液能提高中老年急性髓系白血病患者的疗效，且化疗后骨髓抑制程度轻，恢复快。

关键词: 斑蝥素, 白血病, 双表型, 急性, 药物疗法

Abstract: Objective  To observe the efficacy of sodium cantharidate vitamin B6 injection combined with chemotherapy for acute leukemia patients. Methods  All 113 acute leukemia patients were divided into therapeutic group (81 cases) and control group (32 cases) by whether to inject sodium cantharidate vitamin B6 injection or not. The two groups chose the standard chemotherapy, therapeutic group added sodium cantharidate vitamin B6 injection while the control group not. The remission, suppression situation of bone marrow after chemotherapy, time of marrow restoration and other toxic effects were observed. Results  In the therapeutic group, there were 39 (48.15%) cases of complete remission (CR), 31 (38.27%) cases of partial remission (PR), 11 (13.58%) cases of no remission (NR). In the control group, there were 10 (31.25%) cases of CR, 10 (31.25%) cases of PR and 12 (37.50%) cases of NR, the remission rate in the therapeutic group was higher than the control group, there was significant difference between the two groups (χ2=8.270， P=0.016）. The remission rates of middleaged and elderly patients in therapeutic group were higher than that in control group (χ2=6.360, P=0.042; χ2=6.432, P=0.040), but there was no difference between young patients of therapeutic group and control group (χ2=1.829, P=0.401). The remission rate of acute myeloid leukemia patients in therapeutic group was higher than that control group (χ2=11.411, P=0.003), but there was no difference between acute lymphocytic leukemia patients of therapeutic group and control group (χ2=1.739, P=0.419). The inhibition of granulocytic and thrombocyte was better than that in control group (Z=-2.142, P=0.032;Z=-2.490, P=0.013), while no difference in hemoglobin between the two groups (Z=-0.483, P=0.629).The time of marrow restoration in therapeutic group ［(6.26±1.34) days］ was shorter than that in control group ［(11.33±2.18) days］(t=-14.186, P=0.000）. Conclusion  Sodium cantharidate vitamin B6 injection combined with chemotherapy can improve the efficacy of acute leukemia in elderly patients, also relieve the suppression of bone marrow after chemotherapy.

Key words: Cantharidin, Leukemia, biphenotypic, acute, Drug therapy