国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (10): 785-788.

• 综述 • 上一篇    下一篇

CD4+T细胞在肝细胞癌中的作用

许秀华, 向晓星   

  1. 225501 苏北人民医院消化内科 扬州大学临床医学院
  • 出版日期:2013-10-08 发布日期:2013-09-23
  • 通讯作者: 向晓星，E-mail:yzxiangxx@sina.com E-mail:xiangxx1965@yahoo.com.cn

Roles of CD4+ T lymphocytes in hepatocellular carcinoma

XU  Xiu-Hua, XIANG  Xiao-Xing   

  1. Department of Gastroenterology, Northern Jiangsu People's Hospital; Clinical Medical College of Yangzhou University, Yangzhou 225501, China
  • Online:2013-10-08 Published:2013-09-23
  • Contact: XIANG Xiao-xing, E-mail: xiangxx1965@yahoo.com.cn E-mail:xiangxx1965@yahoo.com.cn

PDF

1512

摘要： CD4+T细胞为一系列多功能细胞，研究发现肝细胞癌中大部分CD4+T细胞亚群可通过活化或抑制机体固有免疫细胞、适应性免疫细胞及非免疫细胞等，参与肿瘤血管生成及浸润、肿瘤细胞凋亡、急性期蛋白及促癌基因的表达，进而发挥肿瘤促进或抑制作用。

关键词: 癌, 肝细胞, 免疫, font-size: 14pt, mso-bidi-font-family: 宋体, mso-font-kerning: 1.0pt, mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA" lang="EN-US">CD4+ T 细胞

Abstract: As a series of multifunctional cells, recent studies indicate that most of the CD4+ T lymphocyte subsets involve in the tumor angiogenesis and invasion, the apoptosis of tumor cells, and the expression of acute phase proteins and cancer-promoting genes by activating or inhibiting the innate immune cells, the adaptive immune cells and non-immune cells, thus function as tumor promoters or inhibitors in hepatocellular carcinoma.

Key words: Carcinoma, hepatocellular, Immunity, CD4+ T lymphocytes