关键词: 乳腺肿瘤, 预后, 分子亚型, 临床特征

Abstract: Objective To investigate the clinical characteristics and prognosis of patients with different molecular subtypes of breast cancer. Methods A cohort of 716 breast cancer patients which had clear immunohistochemical detection were investiged.Their molecular subtypes were categorized as luminal A, luminal B,HER-2 over-expressing and basal-like subtypes,based on detection of ER,PR,Her-2 expression, and the clinical data including characteristics, relapse , prognosis and prognostic factors of the patients with different subtypes of breast cancer were analyzed retrospectively. Results There were no significant differences among different molecular subtypes at the age,menopausal status, production times, clinical stage,and radiation therapy(P>0.05). There were significant differences among different molecular subtypes at axillary lymph node status, tumer size and operation method and chemotherapy regimens(P<0.05). Univariate and multivariate analyses showed that clinical stage，axillary lymph node status and molecular typing were independent prognostic factors affecting long-term survisal rate. Conclusion Breast cancer patients in different subtypes have different long-term survival rate. The patients in basal-like subtype have the worst long-term survival rate. Molecular subtypes may provide important information to predict the prognosis of breast cancer.

Key words: Breast neoplasms, Prognosis, Molecular subtype, Clinicopathological characteristics