国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (6): 412-415.

• 综述 • 上一篇    下一篇

肿瘤转移动物模型

刘军,崔淑香   

  1. 山东省医学科学院药物研究所药理室;济南大学山东省医学科学院医学与生命科学院;山东省罕少见病重点实验室

  • 出版日期:2013-06-08 发布日期:2013-05-24
  • 通讯作者: 崔淑香,E-mail: sxccui@sina.com E-mail:sxccui@sina.com
  • 基金资助:

    国家自然科学基金(81072665

Animal models of cancer metastasis

LIU  Jun, CUI  Shu-Xiang   

  1. Department of Pharmacology, Institute of Materia Medica, Shandong Academy of Medical Sciences; School of Medicine and Life Sciences, University of Jinan- Shandong Academy of Medical Sciences; Key Laboratory for Rare Disease of Shandong Province, Jinan 250062,  China
  • Online:2013-06-08 Published:2013-05-24
  • Contact: CUI Shu-xiang E-mail:sxccui@sina.com

摘要: 研究肿瘤转移需要建立与临床病理过程相近的肿瘤转移动物模型。目前动物模型主要有基因工程模型和异种移植模型,这对探讨肿瘤转移机制、探索实验治疗手段提供了可能的研究工具。其中,细胞株的筛选、实时检测成像技术等都是非常重要的因素。

关键词: 肿瘤转移, 动物, 细胞系, 信号检测

Abstract: Animal models using for research the cancer matestasis should be entirely similar to the clinical pathological process in patients. Currently, two kinds of animal models with genetic engineering and human tumor xenografts are available in laboratory, which provide a possible research tool to investigate the mechanism of tumor metastasis and explore the experimental treatment. In these models, the techniques including how to select the cell lines and using real-time imaging detection are very important factors.

Key words: Neoplasm metastasis, Animals, Cell line, Signal detection