国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (5): 392-395.

• 论著 • 上一篇    下一篇

大肠癌术后肝转移高危因素研究

蒋玥, 王阿曼, 张洁, 班丽英, 周涛   

  1. 061001河北省沧州中西医结合医院肿瘤内科（蒋玥）；116011大连医科大学附属第一医院肿瘤内科（王阿曼、张洁、班丽英、周涛）
  • 出版日期:2013-05-08 发布日期:2013-05-15
  • 通讯作者: 周涛 E-mail:zhoutao1967@163.com

Analysis of high risk factors of liver metastasis in patients with postoperative colorectal cancer

JIANG  Yue, WANG  A-Man, ZHANG  Jie, BAN  Li-Ying, ZHOU  Tao   

  1. Department of Oncology, Cangzhou Tegrated Traditional Chinese and Western Medicine Hospital of Hebei Province, Cangzhou 061001, China
  • Online:2013-05-08 Published:2013-05-15
  • Contact: Zhou Tao E-mail:zhoutao1967@163.com

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摘要： 目的 筛选大肠癌根治术后发生肝转移的高危因素，并建立数学模型。方法 分析168例患者5年随访资料，logistics回归明确术后肝转移的高危因素，ROC检验建立数学模型。结果 全组3年和5年肝转移发生率为25.0%和33.3%，高危因素为淋巴结转移、肿瘤浸润深度、组织学分级及术前肿瘤标志物水平，数学模型为logit(P)=-0.931+0.973×淋巴结转移+0.302×肿瘤浸润深度+0.637×组织学分级+0.042×术前肿瘤标志物水平。结论 大肠癌术后肝转移的高危因素为淋巴结转移、肿瘤浸润深度、组织学分级及术前肿瘤标志物水平，并可建立数学模型。

关键词: 结直肠肿瘤, 肿瘤转移, 肝, 危险因素

Abstract: Objective To screen the risk factors of liver metastasis in patients with postoperative colorectal cancer and to set up a mathematic model. Methods  One hundred and sixty-eight patients received radical surgery were retrospectively analyzed. Logistics model regression was used to identify the risk factors and ROC test to complete a mathematic model. Results The 3 and 5-year incidence rate of liver metastasis was 25.0% and 33.3%, respectively. The risk factors of liver metastasis were lymph node metastasis (LNM), tumor invasive depth (TID), histological grading (G) and preoperative serum tumor markers (PSM). The mathematic model was: logit (P)=-0.931+0.973×LNM+0.302×TID+0.637×G+0.042×PSM. Conclusion The risk factors of liver metastasis were LNM, TID, G and PSM, and the mathematic model could be set up.

Key words: Colorectal neoplasms, Neoplasm metastasis, Liver, Risk factors