国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (5): 381-384.

• 论著 • 上一篇    下一篇

饮酒量对男性鼻咽癌患者化疗呕吐的影响

潘志格, 刘文其, 王仁生, 范小玲   

  1. 530007南宁，广西医科大学第一附属医院（西院）放疗科

  • 出版日期:2013-05-08 发布日期:2013-05-15
  • 通讯作者: 刘文其 E-mail:liuwenqi999@yahoo.com.cn

Effect of capacity for liquor on vomiting induced by chemotherapy in male patients with nasopharyngeal carcinoma

PAN  Zhi-Ge, LIU  Wen-Qi, WANG  Ren-Sheng, FAN  Xiao-Ling   

  1. Department of Radiation Oncology, First Affiliated Hospital of Guangxi Medical University, Nanning 530007, China

  • Online:2013-05-08 Published:2013-05-15
  • Contact: LIU Wen-qi E-mail:liuwenqi999@yahoo.com.cn

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摘要： 目的 探讨单次最大饮酒量对男性鼻咽癌患者化疗呕吐的影响。方法 48例男性鼻咽癌患者采用统一问卷进行调查并根据单次最大乙醇摄入量分为两组：A组(小酒量组0～50 g)和B组(大酒量组＞50 g)。观察两组患者第1周期诱导化疗后的呕吐反应及止吐治疗的情况。结果 两组患者化疗所致呕吐的发生率分别为52.0%和17.4%，两组差异有统计学意义(χ2 =6.273, P＜0.05)。A组0度、1度、2度及3度呕吐的发生率分别为48.0%、20.0%、20.0%、12.0%，B组0度、1度、2度及3度呕吐的发生率分别为82.6%、13.0%、4.4%、0，两组差异有统计学意义(χ2 =6.013, P=0.024)。两组患者化疗急性和延迟性呕吐的完全控制率分别为：48.0%和82.6%(χ2 =6.273, P=0.012)，36.0%和65.2%(χ2 =4.090, P=0.043)，差异均有统计学意义。结论 随着饮酒量的增加，化疗所致呕吐的发生率明显降低，呕吐的程度明显减轻，而化疗止吐治疗的完全有效率则明显增加。

关键词: 鼻咽肿瘤, 呕吐, 饮酒, 诱导化疗

Abstract: Objective  To explore the effect of the single maximum of alcohol consumption on vomiting induced by chemotherapy in male patients with nasopharyngeal carcinoma. Methods  According to the single maximum of alcohol consumption, 48 cases of male patients with nasopharyngeal carcinoma were divided into two groups: group A (small capacity for liquor group 10-50 g), group B (large capacity for liquor group ＞50 g). The amount of alcohol intake was assessed by a questionnaire. The responses of vomiting and the effects of antiemetic therapy between the two groups during the first cycle after induction chemotherapy were observed. Results The incidence rates of vomiting induced by chemotherapy between the two groups were 52.0% and 17.4%, respectively. There were significant differences between the two groups (χ2=6.273,  P＜0.05). The incidence rates of grade 0, 1, 2 and 3 of vomiting in group A were 48.0%, 20.0%, 20.0%, 12.0%, in group B were 82.6%, 13.0%, 4.4%, 0, respectively. There were significant differences between the two groups (χ2=6.013,P=0.024). In the two groups, the complete control rate for acute vomit were 48.0% and 82.6% (χ2=6.273,P=0.012), for delayed vomit were 36.0% and 65.2% (χ2=4.090, P=0.043). There were also significant differences between the two groups. Conclusion With the increasing of capacity for liquor, the incidence of vomiting is significantly reduced, the degree of vomiting is distinctly alleviated, and the antiemetic efficacy is distinctly increased.

Key words: Nasopharyngeal neoplasms, Vomiting, Alcohol drinking, Induction chemotherapy