国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (5): 350-353.

• 综述 • 上一篇    下一篇

乳腺癌干细胞研究进展

韦静妮, 周福祥   

  1. 430071武汉大学中南医院放化疗科,湖北省肿瘤医学临床研究中心,肿瘤生物学行为湖北省重点实验室
  • 出版日期:2013-05-08 发布日期:2013-05-15
  • 通讯作者: 周福祥 E-mail:happyzhoufx@sina.com

Advances in breast cancer stem cells

WEI  Jing-Ni, ZHOU  Fu-Xiang   

  1.  Department of Radiation Oncology, Zhongnan Hospital of Wuhan University; Hubei Cancer Clinical Study Center, Hubei Key Laboratory of Tumor Biological Behavior, Wuhan 430071, China
  • Online:2013-05-08 Published:2013-05-15
  • Contact: ZHOU Fu-xiang E-mail:happyzhoufx@sina.com

摘要: 乳腺癌干细胞与乳腺癌的放疗抵抗性和化疗耐受性有关,特定表面分子标志与不同乳腺癌分子分型相关。目前,针对乳腺癌干细胞的抑制剂正逐步进入临床试验研究并在临床上使用。乳腺癌干细胞同时也是转移的源泉,它和循环肿瘤细胞之间存在一些共同点。总之,探究乳腺癌干细胞的各种特性有利于开发乳腺癌干细胞在临床的应用。

关键词: 肿瘤干细胞, 乳腺肿瘤

Abstract: Breast cancer stem cells (BCSCs) play an important role in radiation and chemotherapy resistance. Different cancer subtypes mean different BCSCs. Inhibitors for BCSCs are gradually explored in clinical trials. Circulating tumor cells (CTCs) are crucial process to tumor metastasis. CTCs seem to be associated with stem cell phenotype. Therefore, further research for BCSCs will enable us to achieve improvement of their clinical application.

Key words: Neoplasms stem cels, Breast neoplasms