国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (4): 259-263.

• 综述 • 上一篇    下一篇

荜茇明碱抗肿瘤作用及其机制

姚志峰, 姚建新, 刘永彪   

  1. 210029 南京医科大学第一临床医学院肿瘤学系（姚志峰）；江苏联合职业技术学院南京卫生分院医学影像系（姚建新）；南京医科大学第一附属医院肿瘤放射治疗科（刘永彪）
  • 出版日期:2013-04-08 发布日期:2013-03-27
  • 通讯作者: 刘永彪，E-mail: yongbiaoliu@yahoo.com.cn E-mail:yongbiaoliu@yahoo.com.cn
  • 基金资助:

    江苏省高校优势学科建设工程（JX10231801）

Antitumor effect of piplartine and its mechanism

YAO  Zhi-Feng, YAO  Jian-Xin, LIU  Yong-Biao   

  1. Department of Oncology, First Clinical College of Nanjing Medical University，Nanjing 210029，China
  • Online:2013-04-08 Published:2013-03-27
  • Contact: LIU Yong-biao E-mail:yongbiaoliu@yahoo.com.cn

PDF

1718

被引次数

8

摘要： 荜茇明碱是从胡椒科植物中分离出的生物碱（酰胺类）天然产物，具有多种药理作用。近年的研究发现其对多种肿瘤的生长具有抑制作用，是一种潜在的抗肿瘤药物。荜茇明碱能够抑制肿瘤细胞的增殖、诱导细胞周期的阻滞并且促进肿瘤细胞的凋亡。最新的研究表明荜茇明碱的抗肿瘤机制可能与其激活活性氧应激途径密切相关。

关键词: 抗肿瘤药, 细胞凋亡, 活性氧, 荜茇明碱

Abstract: Piplartine is an alkaloids/amide component of Piper species, having diverse pharmacological and biological activities. Recent studies have indicated that piplartine has inhibitory effects on several kinds of tumors and is a potential antitumor drug. It can inhibit the proliferation of tumor cells, cause cell cycle arrest and induce apoptosis. More investigations suggest targeting the reactive oxygen species(ROS) stress-response pathway is closely related to its antitumor activity.

Key words: Antineoplastic agents, Apoptosis, Reactive oxygen species, Piplartine