国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (10): 794-796.

• 论著 • 上一篇    下一篇

尾加压素Ⅱ在肺癌组织中的表达及其临床意义

高鸿敏,李莉,于忠和,田桂珍   

  1. 101149 北京军区263医院呼吸内科（高鸿敏、李莉、田桂珍）；北京军区总医院全军肿瘤诊疗中心（于忠和）
  • 出版日期:2012-10-31 发布日期:2012-10-31
  • 通讯作者: 于忠和，E-mail: zhonghe88@263.net E-mail:zhonghe88@263.net

Expression and clinical significance of urotensin Ⅱ in lung cancer tissue

 GAO  Hong-Min, LI  Li, YU  Zhong-He, TIAN  Gui-Zhen   

  1. Department of Respiratory Medicine， No.263 Hospital of Beijing Military， Beijing 101149， China
  • Online:2012-10-31 Published:2012-10-31
  • Contact: YU Zhong-he， E-mail: zhonghe88@263.net E-mail:zhonghe88@263.net

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摘要： 目的 检测尾加压素Ⅱ（UⅡ）在肺癌患者手术切除肺癌组织中的表达。揭示UⅡ在肺癌患者组织中的表达及其与肺癌病理类型、临床分期的相关性。方法 采用免疫组织化学法观察45例肺癌组织及20例炎性假瘤中UⅡ的表达，分析UⅡ表达与肺癌病理类型及TNM临床分期的相关性。结果 肺癌组织中UⅡ主要分布于肺癌细胞的细胞质中，呈棕黄色颗粒； 非小细胞肺癌组UⅡ表达阳性率61.3%（19/31），与对照组肺炎性假瘤（15.0%,3/20）和小细胞肺癌组（7.1%,1/14）相比，差异有统计学意义（P<0.01）； UⅡ在腺癌中的阳性表达率高达100%。Ⅲ期非小细胞肺癌组织中UⅡ的表达水平（85.7%）明显高于Ⅰ期（16.7%）（P<0.05）。结论 UⅡ广泛存在于非小细胞肺癌尤其是腺癌细胞的细胞质中，且UⅡ表达与病理类型及TNM临床分期密切相关。

关键词: 肺肿瘤, 免疫组织化学, 尾加压素Ⅱ

Abstract: Objective To investigate the expression of urotensin Ⅱ(UⅡ) in the lung cancer tissue from surgical resection of lung cancer patients, and to detect the relationship between UⅡ expression and pathologic types and the clinical stages of lung cancer. Methods The expression rates of UⅡof 45 lung cancer tissues and 20 inflammatory pseudotumor were measured by immunohistochemical assay, and the relationship between UⅡexpression and the pathologic types and clinical stages of lung cancer was analyzed. Results UⅡwas mainly distributed in lung cancer cell cytoplasm, which was tanyellow particles. The positive expression rate of UⅡin nonsmall cell lung cancer was 61.3%(19/31)， which was higher than that in small cell lung cancer（7.1%,1/14） and pulmonary inflammatory pseudotumor（15.0%,3/20）(P<0.01).The positive expression rate of UⅡ was 100% in adenocarcinoma. The positive expression rate of UⅡin staging Ⅲ nonsmall cell lung cancer（85.7%） was higher than that of staging Ⅰ （16.7%）(P<0.05). Conclusion UⅡ exists in the cytoplasm of lung cancer cells, and the expression of UⅡis correlated with the pathological type and TNM staging of lung cancer.

Key words: Lung neoplasms, Immunohistochemistry, UrotensinⅡ