环状RNA在三阴性乳腺癌中的作用机制及临床意义

doi:10.3760/cma.j.cn371439-20240702-00131

摘要/Abstract

摘要：

环状RNA（circRNA）在三阴性乳腺癌（TNBC）中展现出巨大的应用潜力。异常表达的circRNA通过作为微RNA海绵、调控基因表达、与功能蛋白相互作用、编码短肽或蛋白质调控TNBC细胞增殖、凋亡、侵袭、转移及耐药等生物学过程，参与TNBC的发生发展。circRNA是TNBC早期诊断及预后评估的新兴生物标志物，同时也是具有潜在临床价值的治疗新靶点。进一步阐明circRNA在TNBC中的复杂作用机制，可为开发TNBC的精准化治疗策略提供重要的理论依据。

关键词: 三阴性乳腺癌, RNA，环状, 致癌作用, 生物疗法

Abstract:

Circular RNA （circRNA） has shown great application potential in triple-negative breast cancer （TNBC）. The aberrantly expressed circRNAs participate in the occurrence and development of TNBC by acting as microRNA sponges， regulating gene expression， interacting with functional proteins， and encoding short peptides or proteins to regulate the biological processes of TNBC cell proliferation， apoptosis， invasion， metastasis， and drug resistance. circRNAs are emerging biomarkers for early diagnosis and prognosis of TNBC， as well as new therapeutic targets with potential clinical value. Further elucidation of the complex mechanism of circRNAs in TNBC may provide an important theoretical basis for the development of precise therapeutic strategies for TNBC.

Key words: Triple negative breast neoplasms, RNA， circular, Carcinogenesis, Biological therapy

王莉, 肖翰, 黄国福. 环状RNA在三阴性乳腺癌中的作用机制及临床意义[J]. 国际肿瘤学杂志, 2024, 51(12): 774-778.

Wang Li, Xiao Han, Huang Guofu. Mechanism of action and clinical significance of circular RNA in triple negative breast cancer[J]. Journal of International Oncology, 2024, 51(12): 774-778.

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