Nrf2在卵巢癌中的研究进展

doi:10.3760/cma.j.cn371439-20230525-00094

摘要/Abstract

摘要：

核转录因子红系2相关因子2（Nrf2）是调节氧化还原、脂质代谢和蛋白质动态平衡的重要转录因子，在保护机体免受氧化应激损伤中发挥重要作用。近年来，越来越多的研究表明，Nrf2在卵巢癌中通过多种机制被激活，可诱导抗氧化酶增加、改变性激素代谢以及诱导下游靶标发挥作用。深入研究Nrf2促进卵巢癌发展的机制，探索其在耐药中的作用并寻求新的治疗靶点，可为耐药卵巢癌的治疗提供新的思路。

Abstract:

Nuclear factor-erythroid 2-related factor 2 （Nrf2） is an important transcription factor that regulates redox， lipid metabolism and protein dynamic balance， and plays an important role in protecting the body from oxidative stress damage. Recently， more and more studies have shown that Nrf2 is activated in ovarian cancer by various mechanisms to induce increased antioxidant enzymes， change sex hormone metabolism and induce downstream targets. Further studying the mechanism of Nrf2 in promoting the development of ovarian cancer， exploring its role in drug resistance and seeking new therapeutic targets can provide new ideas for the treatment of drug-resistant ovarian cancer.

Key words: Ovarian neoplasms, NF-E2-related factor 2, Antineoplastic combined chemotherapy protocols, Drug resistance, neoplasm

安荣, 刘美华, 王佩晨, 王晓慧. Nrf2在卵巢癌中的研究进展[J]. 国际肿瘤学杂志, 2023, 50(8): 493-497.

An Rong, Liu Meihua, Wang Peichen, Wang Xiaohui. Research progress of Nrf2 in ovarian cancer[J]. Journal of International Oncology, 2023, 50(8): 493-497.

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