放射相关miRNA在乳腺癌放疗中的作用

doi:10.3760/cma.j.cn371439-20220805-00144

摘要/Abstract

摘要：

乳腺癌是女性最常见的肿瘤，而放疗是治疗乳腺癌的重要方法。放疗的效果很大程度上取决于肿瘤细胞的放射敏感性。微小RNA（miRNA）参与乳腺癌放疗反应的关键途径包括DNA损伤修复、凋亡、细胞周期停滞、自噬和相关信号通路。探讨miRNA在调节乳腺癌对放疗的治疗反应及其在相关信号通路中的作用，可为miRNA成为评估乳腺癌诊断、预后和放射疗效的指标提供参考。

关键词: 乳腺肿瘤, 微RNAs, 辐射，电离

Abstract:

Breast cancer is the most common cancer in women, and radiotherapy is an important method of its treatment. The outcome of radiotherapy greatly depends on radiosensitivity of cancer cells. The key pathways of microRNAs （miRNAs） involved in breast cancer radiotherapy response include DNA damage repair, apoptosis, cell cycle arrest, autophagy and related signaling pathways. This article reviews the role of miRNAs in regulating the response of breast cancer to radiotherapy and related signaling pathways. To explore the role of miRNAs in regulating the treatment response of breast cancer to radiotherapy and related signaling pathways, it can provide reference for miRNAs to be used as an indicator to evaluate the diagnosis, prognosis and radiotherapy efficacy of breast cancer.

Key words: Breast neoplasms, MicroRNAs, Radiation, ionizing

金嘉会, 陈存海, 马学真. 放射相关miRNA在乳腺癌放疗中的作用[J]. 国际肿瘤学杂志, 2022, 49(12): 735-738.

Jin Jiahui, Chen Cunhai, Ma Xuezhen. Effects of radiation-associated miRNA in radiotherapy for breast cancer[J]. Journal of International Oncology, 2022, 49(12): 735-738.

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