阿维菌素类药物在抗肿瘤方面的研究进展

doi:10.3760/cma.j.cn371439-20220321-00067

国际肿瘤学杂志 ›› 2022, Vol. 49 ›› Issue (6): 353-356.doi: 10.3760/cma.j.cn371439-20220321-00067

阿维菌素类药物在抗肿瘤方面的研究进展

王丽薇¹, 梁洪生², 杜松林¹, 陈志豪¹, 王晴¹, 高爱丽¹()

¹东北农业大学生命科学学院,哈尔滨 150030
²哈尔滨医科大学附属第一医院神经外科,哈尔滨 150001

收稿日期:2022-03-21 修回日期:2022-04-07 出版日期:2022-06-08 发布日期:2022-06-30
通讯作者: 高爱丽,孔春燕 E-mail:gaoaili2004@163.com
基金资助:
国家自然科学基金(82071368);哈尔滨医科大学杰出青年基金(HYD2020JQ0016)

Research progress of avermectins in anti-tumor

Wang Liwei¹, Liang Hongsheng², Du Songlin¹, Chen Zhihao¹, Wang Qing¹, Gao Aili¹()

¹College of Life Sciences, Northeast Agricultural University, Harbin 150030, China
²Department of Neurosurgery, First Hospital Affiliated of Harbin Medical University, Harbin 150001, China

Received:2022-03-21 Revised:2022-04-07 Online:2022-06-08 Published:2022-06-30
Contact: Gao Aili E-mail:gaoaili2004@163.com
Supported by:
National Natural Science Foundation of China(82071368);Harbin Medical University Outstanding Youth Foundation of China(HYD2020JQ0016)

摘要/Abstract

摘要：

阿维菌素类药物能够影响多种肿瘤的生物学过程,包括肿瘤细胞的增殖和转移、细胞周期阻滞、凋亡和自噬的诱导、肿瘤微环境的调控以及肿瘤干细胞等。阿维菌素类药物在肿瘤治疗中可单独给药,也可联合化疗药物一起使用,逆转肿瘤多药耐药。进一步探索阿维菌素类药物的抗肿瘤机制,可为今后的临床应用提供可靠的实验理论指导。

关键词: 抗肿瘤药, 药理作用分子作用机制, 阿维菌素类药物

Abstract:

Avermectins can affect biological processes of multiple tumor, including tumor cell proliferation and metastasis, cell cycle arrest, induction of apoptosis and autophagy, regulation of tumor microenvironment and tumor stem cells. Avermectins can be administered alone or combined with chemotherapeutic drugs to reverse multidrug resistance. To further explore the anti-tumor mechanism of avermectins will provide reliable experimental and theoretical guidance for future clinical application.

Key words: Antineoplastic agents, Molecular mechanisms of pharmacological action, Avermectins

王丽薇, 梁洪生, 杜松林, 陈志豪, 王晴, 高爱丽. 阿维菌素类药物在抗肿瘤方面的研究进展[J]. 国际肿瘤学杂志, 2022, 49(6): 353-356.

Wang Liwei, Liang Hongsheng, Du Songlin, Chen Zhihao, Wang Qing, Gao Aili. Research progress of avermectins in anti-tumor[J]. Journal of International Oncology, 2022, 49(6): 353-356.

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阿维菌素类药物在抗肿瘤方面的研究进展

Research progress of avermectins in anti-tumor

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