国际肿瘤学杂志

国际肿瘤学杂志 ›› 2019, Vol. 46 ›› Issue (8): 466-470.doi: 10.3760/cma.j.issn.1673-422X.2019.08.004

• 论著 • 上一篇    下一篇

食管癌组织中HIF-1α、OPN的表达及其临床意义

王淼1    刘培俊2   

  1. 1湖北省恩施土家族苗族自治州中心医院肿瘤二科    445000；2湖北省恩施土家族苗族自治州中心医院呼吸内科   445000
  • 收稿日期:2019-05-23 修回日期:2019-06-23 出版日期:2019-08-08 发布日期:2019-10-31
  • 通讯作者: 刘培俊 E-mail:2583770208@qq.com

Expression and clinical significance of HIF-1α and OPN in esophageal cancer tissues

Wang Miao1, Liu Peijun2   

  1. 1Second Department of Oncology, Enshi Tujia and Miao Autonomous Prefecture Central Hospital of Hubei Province, Enshi 445000, China; 2Department of Respiratory Medicine, Enshi Tujia and Miao Autonomous Prefecture Central Hospital of Hubei Province, Enshi 445000, China
  • Received:2019-05-23 Revised:2019-06-23 Online:2019-08-08 Published:2019-10-31
  • Contact: Liu Peijun E-mail:2583770208@qq.com

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摘要： 目的    探讨食管癌组织中缺氧诱导因子-1α（HIF-1α）、骨桥蛋白（OPN）的表达及其临床意义。方法    选取2015年1月至2017年1月湖北省恩施土家族苗族自治州中心医院食管癌患者100例，采用免疫组织化学法检测食管癌及其癌旁组织中HIF-1α、OPN的表达情况，分析HIF-1α、OPN的表达与食管癌患者临床病理特征的关系，以及两者之间的相关性。结果    食管癌组织中HIF-1α、OPN阳性表达率分别为70.00%(70/100)、64.00%(64/100)，均明显高于癌旁组织的14.00%(14/100)、8.00%(8/100)，差异有统计学意义（χ2=64.368，P<0.001；χ2=68.056，P<0.001）；HIF-1α的表达与TNM分期、浸润深度、淋巴结转移相关（χ2=30.159，P<0.001；χ2=17.493，P<0.001；χ2=16.357，P<0.001），与性别、年龄、肿瘤直径、分化程度均无关（均P>0.05）；OPN的表达与TNM分期、浸润深度、淋巴结转移相关（χ2=12.558，P=0.002；χ2=15.395，P<0.001；χ2=17.056，P<0.001），与性别、年龄、肿瘤直径、分化程度均无关（均P>0.05）；食管癌组织中HIF-1α、OPN的表达呈正相关（χ2=61.144，P<0.001，C=0.616）；食管癌组织中HIF-1α、OPN阳性患者2年生存率分别为51.43%、50.00%，明显低于HIF-1α、OPN阴性患者的80.00%、77.78%，差异均有统计学意义（χ2=7.143，P=0.008；χ2=7.407，P=0.006）。结论    HIF-1α、OPN在食管癌组织中呈高表达，且二者高表达可能与食管癌生存预后差有关。

关键词: 食管肿瘤, 缺氧诱导因子1, α亚基, 骨桥蛋白质, 预后

Abstract: Objective  To discuss the expression and clinical significance of hypoxia-inducible factor-1α (HIF-1α) and osteopontin (OPN) in esophageal cancer tissues. Methods  A total of 100 patients with esophageal cancer in Enshi Tujia and Miao Autonomous Prefecture Central Hospital of Hubei Province from January 2015 to January 2017 were selected. The expressions of HIF-1α and OPN in esophageal cancer and adjacent tissues were detected by immunohistochemistry. The relationships between HIF-1α and OPN expressions and clinical pathological characteristics of esophageal cancer patients, as well as the correlation between them were analyzed. Results  The positive rates of HIF-1α and OPN expression in esophageal cancer tissues were 70.00% (70/100) and 64.00% (64/100), which were significantly higher than the 14.00% (14/100) and 8.00% (8/100) in adjacent tissues, and the differences were statistically significant (χ2=64.368, P<0.001; χ2=68.056, P<0.001). The expression of HIF-1α was correlated with TNM stage, depth of invasion and lymph node metastasis (χ2=30.159, P<0.001; χ2=17.493, P<0.001; χ2=16.357, P<0.001), but it was not correlated with sex, age, tumor diameter and differentiation (all P>0.05). The expression of OPN was correlated with TNM stage, depth of invasion and lymph node metastasis (χ2=12.558, P=0.002; χ2=15.395, P<0.001; χ2=17.056, P<0.001), but it was not correlated with sex, age, tumor diameter and differentiation (all P>0.05). There was the positive correlation between HIF-1α and OPN expression in esophageal cancer tissues (χ2=61.144, P<0.001, C=0.616). The 2-year survival rates of HIF-1α and OPN positive patients in esophageal cancer tissues were 51.43% and 50.00% respectively, which were significantly lower than those of HIF-1α and OPN negative patients (80.00% and 77.78%), and the differences were statistically significant (χ2=7.143, P=0.008; χ2=7.407, P=0.006). Conclusion  HIF-1α and OPN are highly expressed in esophageal cancer tissues, and their high expression may be related to poor survival prognosis of esophageal cancer.

Key words: Esophageal neoplasms, Hypoxia-inducible factor 1, alpha subunit, Osteopontin, Prognosis