国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (8): 604-607.doi: 10.3760/cma.j.issn.1673-422X.2017.08.012

• 综述 • 上一篇    下一篇

瘤内异质性分析指导乳腺癌精准医疗

易宗毕,马飞   

  1. 100021 国家癌症中心 中国医学科学院 北京协和医学院肿瘤医院肿瘤内科
  • 出版日期:2017-08-08 发布日期:2017-07-21
  • 通讯作者: 马飞，Email: drmafei@126.com E-mail:drmafei@126.com
  • 基金资助:

    北京市科技计划项目（D161100000816004）

Analysis of intratumor heterogeneity in breast cancer precision medicine

Yi Zongbi, Ma Fei   

  1. Department of Medical Oncology, National Cancer Center, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
  • Online:2017-08-08 Published:2017-07-21
  • Contact: Ma Fei, Email: drmafei@126.com E-mail:drmafei@126.com
  • Supported by:

    Science and Technology Planning Project of Beijing of China (D161100000816004)

PDF

1153

摘要： 瘤内异质性与肿瘤的发生、转移和耐药等密切相关，是近年来肿瘤领域研究的热点，也是精准医疗的突破口。很多研究已经证实乳腺癌存在广泛的瘤内异质性，给临床上寻找理想的肿瘤标志物和精准治疗带来了极大的困难。深入解析肿瘤异质性的特征、产生机制以及研究临床可量化肿瘤异质性的方法是肿瘤精准治疗的关键。

关键词: 乳腺肿瘤, 瘤内异质性, 精准医疗

Abstract: As a breakthrough of precision medicine, intratumor heterogeneity is a research hotspot and is correlated to tumorigenesis, metastasis and resistance to therapies. In breast cancer, evidence of intratumor heterogeneity has been documented by numerous studies and it is the main obstacle to find ideal tumor markers and personalized medicine. Further analysis including the feature and generation mechanism of intratumor heterogeneity and the methods to assessment intratumor heterogeneity in the clinic are the key to cancer precision medicine.

Key words: Breast neoplasms, Intra-tumor heterogeneity, Precision medicine