国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (8): 565-568.doi: 10.3760/cma.j.issn.1673-422X.2017.08.002

• 论著 • 上一篇    下一篇

OTUB1在乳腺癌组织中的表达及临床意义 

 段菲, 张金玉, 刘静, 马振峰, 崔乃鹏, 刘现义, 陈保平   

  1. 071000保定，河北大学医学院（段菲、张金玉）；河北省沧州市人民医院妇产科（刘静）；河北大学附属医院乳腺外科（马振峰、崔乃鹏、刘现义、陈保平）
  • 出版日期:2017-08-08 发布日期:2017-07-21
  • 通讯作者: 陈保平，Email: cbp1962@126.com E-mail:cbp1962@126.com

Expression and clinical significance of OTUB1 in breast cancer

Duan Fei*, Zhang Jinyu, Liu Jing, Ma Zhenfeng, Cui Naipeng, Liu Xianyi, Chen Baoping   

  1. Medical College of Hebei University, Baoding 071000, China
  • Online:2017-08-08 Published:2017-07-21
  • Contact: Chen Baoping, Email: cbp1962@126.com E-mail:cbp1962@126.com

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摘要： 目的 探讨OTUB1在乳腺癌组织中的表达水平及其临床意义。方法应用免疫组织化学染色SP法分别检测78例乳腺癌组织和30例癌旁正常乳腺组织标本中OTUB1蛋白的表达水平，并分析该蛋白与乳腺癌临床病理特征之间的关系。结果 OTUB1在乳腺癌组织中的阳性表达率［66.7%（52/78）］显著高于癌旁正常乳腺组织［30.0%（9/30）］，差异有统计学意义（χ2＝11.851，P=0.001）。OTUB1表达与乳腺癌患者淋巴结转移（χ2＝5.029，P=0.025）、术后分期（χ2＝4.478，P=0.034）、人类表皮生长因子受体2（HER2）表达（χ2＝8.775，P=0.003）、P53表达（χ2＝4.708，P=0.030）、雌激素受体（ER）表达（χ2=10.364，P=0.001）、分子分型（χ2＝10.934，P=0.012）有关，而与年龄（χ2=2.194，P=0.139）、绝经状态（χ2=1.843，P=0.175）、肿瘤大小（χ2=0.643，P=0.423）、组织学分级（χ2=3.580，P=0.167）、孕激素受体（PR）表达（χ2=3.371，P=0.066）及Ki67表达（χ2=1.345，P=0.246）无关。结论 OTUB1蛋白在乳腺癌组织中的表达上调，并与淋巴结转移、术后TNM分期、HER2、P53、ER表达及分子分型有关，提示OTUB1蛋白的表达与乳腺癌的发生、转移相关。

关键词: 乳腺肿瘤, 免疫组织化学, OTUB1

Abstract: Objective  To explore the expression level of OTUB1 and its clinical significance in breast cancer. Methods  Immunohistochemistry was used to detect the expression level of OTUB1 in 78 cases of breast cancer tissues and 30 cases of normal breast tissue adjacent to carcinoma, and the relationships between OTUB1 and the clinical pathological features of breast cancer were analyzed. Results  The positive expression rate of OTUB1 in breast cancer tissues ［66.7% (52/78)］ was significantly higher than that in adjacent normal breast tissues ［30.0% (9/30)］, with a statistically significant difference (χ2=11.851, P=0.001). OTUB1 expression level was related to the lymph node metastasis (χ2=5.029, P=0.025), postoperative TNM staging (χ2=4.478, P=0.034), expression of human epidermal growth factor receptor2 (HER2) (χ2＝8.775,P=0.003), expression of P53 (χ2=4.708, P=0.030), expression of estrogen receptor (ER) (χ2=10.364,P=0.001) and molecular subtypes (χ2＝10.934, P=0.012). However, OTUB1 expression level in breast cancer was not related to the age (χ2=2.194, P=0.139), menopausal status (χ2=1.843, P=0.175), tumor size (χ2=0.643, P=0.423), histological grade (χ2=3.580, P=0.167), expression of progestin receptor (PR) (χ2=3.371, P=0.066) and expression of Ki67 (χ2=1.345, P=0.246). Conclusion  OTUB1 expression level increases in breast cancer, which is associated with the lymph node metastasis, TNM staging, expressions of HER-2, P53, ER and molecular subtypes of breast cancer. It suggests that the expression of OTUB1 is related to the progression and metastasis of breast cancer.

Key words: Breast neoplasms, Immunohistochemistry, OTUB1