长非编码RNA在白血病中的研究进展

doi:10.3760/cma.j.issn.1673422X.2016.12.018

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (12): 950-952.doi: 10.3760/cma.j.issn.1673422X.2016.12.018

长非编码RNA在白血病中的研究进展

胡林辉, 熊术道

安徽医科大学第二附属医院血液科安徽医科大学血液病研究中心

出版日期:2016-12-08 发布日期:2016-11-02
基金资助:
国家自然科学基金（81272259）

Long noncoding RNA in leukemia

HU Lin-Hui, XIONG Shu-Dao

Department of Hematology, Second Hospital of Anhui Medical University, Hematological Disease Research Center of Anhui Medical University, Hefei 230601, China

Online:2016-12-08 Published:2016-11-02
Supported by:
National Natural Science Foundation of China (81272259)

摘要/Abstract

摘要： 最近研究表明，一些长非编码RNA（lncRNA）在伴混合谱系白血病（MLL）基因重排、BCRABL、早幼粒白血病基因和维甲酸受体α（PMLRARα）以及急性髓系白血病1(AML1)ETO等融合基因的白血病中的表达具有特异性，并与疾病的发生、发展和预后密切相关。表达特异的lncRNA有望为白血病的诊断和治疗提供新策略，并对临床预后提供指导。

关键词: 白血病, 染色体核型, 长非编码RNA

Abstract: Recent studies show that some long noncoding RNA (lncRNA) is specifically expressed in leukemia with mixed lineage leukemia (MLL)rearranged, BCRABL, promyelocytic leukemiaretinoic acid receptor α (PMLRARα), and acute myeloid leukemia 1 (AML1)ETO fusion gene, which is closely related to the occurrence, development and prognosis of leukemia. Specifically expressed lncRNA may provide new strategies for the diagnosis and treatment, which may provide a guidance for clinical prognosis of leukemia.

Key words: Leukemia, Karyotype, Long noncoding RNA

胡林辉, 熊术道. 长非编码RNA在白血病中的研究进展[J]. 国际肿瘤学杂志, 2016, 43(12): 950-952.

HU Lin-Hui, XIONG Shu-Dao. Long noncoding RNA in leukemia[J]. Journal of International Oncology, 2016, 43(12): 950-952.

参考文献

［1］ Iyer MK, Niknafs YS, Malik R, et al. The landscape of long noncoding RNAs in the human transcriptome［J］. Nat Genet, 2015, 47(3): 199208. DOI: 10.1038/ng.3192. ［2］ Rinn JL, Kertesz M, Wang JK, et al. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs［J］. Cell, 2007, 129(7): 13111323. ［3］ Carrieri C, Cimatti L, Biagioli M, et al. Long noncoding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat［J］. Nature, 2012, 491(7424): 454457. DOI: 10.1038/nature11508. ［4］ Yoon JH, Abdelmohsen K, Srikantan S, et al. LincRNAp21 suppresses target mRNA translation［J］. Mol Cell, 2012, 47(4): 648655. DOI: 10.1016/j.molcel.2012.06.027. ［5］ Tay Y, Rinn J, Pandolfi PP. The multilayered complexity of ceRNA crosstalk and competition［J］. Nature, 2014, 505(7483): 344352. DOI: 10.1038/nature12986. ［6］ RodriguezMalavé NI, Rao DS. Long noncoding RNAs in hematopoietic malignancies［J］. Brief Funct Genomics, 2015, In press. ［7］ Fang K, Han BW, Chen ZH, et al. A distinct set of long noncoding RNAs in childhood MLLrearranged acute lymphoblastic leukemia: biology and epigenetic target［J］. Hum Mol Genet, 2014, 23(12): 32783288. DOI: 10.1093/hmg/ddu040. ［8］ Fernando TR, RodriguezMalave NI, Waters EV, et al. LncRNA expression discriminates karyotype and predicts survival in Blymphoblastic leukemia［J］. Mol Cancer Res, 2015, 13(5): 839851. DOI: 10.1158/15417786.MCR150006T. ［9］ RodriguezMalavé NI, Fernando TR, Patel PC, et al. BALR6 regulates cell growth and cell survival in Blymphoblastic leukemia［J］. Mol Cancer, 2015, 14: 214. DOI: 10.1186/s129430150485z. ［10］ Guo G, Kang Q, Zhu X, et al. A long noncoding RNA critically regulates BcrAblmediated cellular transformation by acting as a competitive endogenous RNA［J］. Oncogene, 2015, 34(14): 17681779. DOI: 10.1038/onc.2014.131. ［11］ Guo G, Kang Q, Chen Q, et al. High expression of long noncoding RNA H19 is required for efficient tumorigenesis induced by BcrAbl oncogene［J］. FEBS Lett, 2014, 588(9): 17801786. DOI: 10.1016/j.febslet. 2014.03.038. ［12］ Le Beau MM, Bitts S, Davis EM, et al. Recurring chromosomal abnormalities in leukemia in PMLRARA transgenic mice parallel human acute promyelocytic leukemia［J］. Blood, 2002, 99(8): 29852991. ［13］ Zeng C, Yu X, Lai J, et al. Overexpression of the long noncoding RNA PVT1 is correlated with leukemic cell proliferation in acute promyelocytic leukemia［J］. J Hematol Oncol, 2015, 8(1): 126. DOI: 10.1186/s1304501502234. ［14］ Chinen Y, Sakamoto N, Nagoshi H, et al. 8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia［J］. J Hematol Oncol, 2014, 7: 68. DOI: 10.1186/s1304501400682. ［15］ Zeng C, Xu Y, Xu L, et al. Inhibition of long noncoding RNA NEAT1 impairs myeloid differentiation in acute promyelocytic leukemia cells［J］. BMC Cancer, 2014, 14: 693. DOI: 10.1186/1471240714693. ［16］ Wang H, Li W, Guo R, et al. An intragenic long noncoding RNA interacts epigenetically with the RUNX1 promoter and enhancer chromatin DNA in hematopoietic malignancies［J］. Int J Cancer, 2014, 135(12): 27832794. DOI: 10.1002/ijc.28922. ［17］ Garzon R, Volinia S, Papaioannou D, et al. Expression and prognostic impact of lncRNAs in acute myeloid leukemia［J］. Proc Natl Acad Sci USA, 2014, 111(52): 1867918684. DOI: 10.1073/pnas.1422050112.

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长非编码RNA在白血病中的研究进展

Long noncoding RNA in leukemia

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